bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester

Base Information

• Chemical Name: bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester
• CAS No.: 74283-75-3
• Molecular Formula: C₂₀H₂₆N₂O₂
• Molecular Weight: 326.439
• Mol file: 74283-75-3.mol

Synonyms:bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester

Chemical Property of bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester

There total 9 articles about bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-bromo-N,N-dimethylaniline (586-77-6) + ethyl acetate (141-78-6) → bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester (74283-75-3)

Guidance literature:

With potassium phosphate; (1,10-phenanthroline)(triphenylphosphine)CuBr; tri-tert-butylphosphonium tetrafluoroborate; palladium diacetate; In N,N-dimethyl-formamide; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1002/adsc.201100172

Reference yield: 72.0%

di-morpholin-4-yl-acetic acid ethyl ester (6397-31-5) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester (74283-75-3)

Guidance literature:

With acetic acid; at 100 ℃; for 1h;

Reference yield: 58.0%

glyoxylic acid ethyl ester (924-44-7) + N,N-dimethyl-aniline (121-69-7,77733-26-7) → bis-(4-dimethylaminophenyl)hydroxyacetic acid ethyl ester (74283-75-3)

Guidance literature:

With Selectfluor; In 1,2-dichloro-ethane; at 90 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c3cc45084h

upstream raw materials:

di-morpholin-4-yl-acetic acid ethyl ester

N,N-dimethyl-aniline

glyoxylic acid ethyl ester

4-bromo-N,N-dimethylaniline

Refernces

• 1、 Jadhav, Santosh D.,Bakshi, Debanjan,Singh, Anand. "Visible Light Mediated Organocatalytic Activation of Ethyl Bromofluoroacetate: Coupling with Indoles and Anilines". . p. 10187 - 10196. Retrieved 2015.
• 2、 Lv, Yunhe,Zheng, Yiying,Li, Yan,Xiong, Tao,Zhang, Jingping,Liu, Qun,Zhang, Qian. "Reductive amination of tertiary anilines and aldehydes". . p. 8866 - 8868. Retrieved 2013/09/24.