N-3-5-DINITROBENZOYL-DL-PHENYLGLYCINE

Base Information

• Chemical Name: N-3-5-DINITROBENZOYL-DL-PHENYLGLYCINE
• CAS No.: 74958-71-7
• Molecular Formula: C15H11 N3 O7
• Molecular Weight: 345.268
• Hs Code.: 2924299090
• Mol file: 74958-71-7.mol

Synonyms:Benzeneaceticacid, a-[(3,5-dinitrobenzoyl)amino]-, (?à)-; 3,5-Dinitro-a-phenylhippuric acid;N-(3,5-Dinitrobenzoyl)-DL-phenylglycine

Chemical Property of N-3-5-DINITROBENZOYL-DL-PHENYLGLYCINE

Chemical Property:

• Melting Point: 240 °C (dec.)(lit.)
• PSA: 161.53000
• LogP: 3.67990
• Storage Temp.: -20°C

Purity/Quality:

99% ^*data from raw suppliers

N-(3,5-Dinitrobenzoyl)-DL-α-phenylglycine Aldrich ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-3-5-DINITROBENZOYL-DL-PHENYLGLYCINE

There total 2 articles about N-3-5-DINITROBENZOYL-DL-PHENYLGLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

phenylglycin (2835-06-5) + 3,5-dinitrobenoyl chloride (99-33-2) → (R)-(-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine (74958-71-7)

Guidance literature:

With methyloxirane; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.0c00027

Reference yield:

→ (R)-(-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine (74958-71-7)

Guidance literature:

Amino-phenyl-essigsaeure, 3,5-Dinitro-benzoylchlorid;

Reference yield: 78.0%

methanol (67-56-1) + (R)-(-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine (74958-71-7) → (R,S)-N-(3,5-dinitrobenzoyl)-phenylglycine methyl ester

Guidance literature:

With hydrogenchloride; for 1h; Reflux;

DOI:10.1021/acs.joc.0c00027

upstream raw materials:

phenylglycin

3,5-dinitrobenoyl chloride

Downstream raw materials:

(S)-(+)-N-(3,5-dinitrobenzoyl)-α-phenylglycine

(R)-(-)-N-(3,5-dinitrobenzoyl)-α-phenylglycine

Refernces

• 1、 Sung, Ji Yeong,Choi, Seung Hyuck,Hyun, Myung Ho. "Preparation of a New Chiral Stationary Phase Based on Macrocyclic Amide Chiral Selector for the Liquid Chromatographic Chiral Separations". . p. 253 - 258. Retrieved 2016/02/26.