7-BROMO-2-METHYL-2H-INDAZOLE

Base Information

• Chemical Name: 7-BROMO-2-METHYL-2H-INDAZOLE
• CAS No.: 701910-14-7
• Molecular Formula: C8H7BrN2
• Molecular Weight: 211.061
• Hs Code.: 2933990090
• Mol file: 701910-14-7.mol

Synonyms:7-Bromo-2-methyl-2H-indazole;

Chemical Property of 7-BROMO-2-METHYL-2H-INDAZOLE

Chemical Property:

• Refractive Index: 1.663
• Boiling Point: 322.7 °C at 760 mmHg
• Flash Point: 148.9 °C
• PSA: 17.82000
• Density: 1.6 g/cm³
• LogP: 2.33580
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

7-Bromo-2-methyl-2h-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BROMO-2-METHYL-2H-INDAZOLE

There total 7 articles about 7-BROMO-2-METHYL-2H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

dimethyl sulfate (77-78-1) + 7-bromo-1H-indazole (53857-58-2) → 7-bromo-2-methyl-2H-indazole (701910-14-7)

Guidance literature:

In toluene; at 110 ℃; for 4h;

Reference yield: 53.2%

7-bromo-1H-indazole (53857-58-2) + methyl iodide (74-88-4) → 7-bromo-2-methyl-2H-indazole (701910-14-7) + 7-bromo-1-methyl-1H-indazole (1000576-59-9)

Guidance literature:

7-bromo-1H-indazole; With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 25 ℃; for 3h;

Reference yield: 53.0%

7-bromo-2H-indazole (845751-59-9,53857-58-2) + dimethyl sulfate (77-78-1) → 7-bromo-2-methyl-2H-indazole (701910-14-7)

Guidance literature:

In toluene; at 110 ℃; for 16h;

DOI:10.1021/jm201710f

upstream raw materials:

dimethyl sulfate

7-bromo-1H-indazole

7-bromo-2H-indazole

2-bromo-6-methylaniline

Downstream raw materials:

7-(2,4-dichloro-phenyl)-2-methyl-2H-indazole

7-bromo-2,3-dimethyl-2H-indazole

C₁₅H₁₃BrN₂S

C₂₀H₂₀Cl₂N₄O₂

Refernces

• 1、 -. "CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF". Paragraph 0344-0346. . Retrieved 2019/10/23.
• 2、 -. "NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS". Page/Page column 40. . Retrieved 2010/04/25.