2-Hydroxy-7-methoxy-1-naphthaldehyde

Base Information

• Chemical Name: 2-Hydroxy-7-methoxy-1-naphthaldehyde
• CAS No.: 75965-66-1
• Molecular Formula: C₁₂H₁₀O₃
• Molecular Weight: 202.21
• Hs Code.: 2914500090
• European Community (EC) Number: 849-897-8
• Nikkaji Number: J1.652.349F
• Mol file: 75965-66-1.mol

Synonyms:2-hydroxy-7-methoxy-1-naphthaldehyde;75965-66-1;2-HYDROXY-7-METHOXYNAPHTHALENE-1-CARBALDEHYDE;MFCD22416262;SCHEMBL5229299;WQGADZACBGKOHW-UHFFFAOYSA-N;AKOS022647003;SY028268;CS-0374054;F11690;A915247

Chemical Property of 2-Hydroxy-7-methoxy-1-naphthaldehyde

Chemical Property:

• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 202.062994177
• Heavy Atom Count: 15
• Complexity: 229

Purity/Quality:

99% ^*data from raw suppliers

2-Hydroxy-7-methoxy-1-naphthaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C=CC(=C2C=O)O

Technology Process of 2-Hydroxy-7-methoxy-1-naphthaldehyde

There total 9 articles about 2-Hydroxy-7-methoxy-1-naphthaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

2,7-dimethoxy-1-naphthalenecarbaldehyde (51385-93-4) → 2-hydroxy-7-methoxynaphthalene-1-carbaldehyde (75965-66-1)

Guidance literature:

With dichloromethyl ether; titanium tetrachloride; In dichloromethane; at 0 ℃;

DOI:10.1002/cjoc.202000342

Reference yield: 73.0%

7-methoxy-2-naphthol (5060-82-2) + orthoformic acid triethyl ester (122-51-0) → 2-hydroxy-7-methoxynaphthalene-1-carbaldehyde (75965-66-1)

Guidance literature:

7-methoxy-2-naphthol; orthoformic acid triethyl ester; With aniline; for 20h; Reflux;

With hydrogenchloride; In ethanol; at 60 ℃; for 0.5h;

Reference yield: 57.0%

formic acid 7-methoxy-naphthalen-2-yl ester → 2-hydroxy-7-methoxynaphthalene-1-carbaldehyde (75965-66-1)

Guidance literature:

With boron trichloride; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

DOI:10.1515/znb-2001-1113

upstream raw materials:

2,7-dimethoxy-1-naphthalenecarbaldehyde

chloroform

7-methoxy-2-naphthol

dimethyl sulfate

Downstream raw materials:

9-methoxy-2-methyl-benzo[f]chromen-3-one

2-Benzyloxy-7-methoxy-naphthalene-1-carbaldehyde

Refernces

• 1、 Luo, Na,Fang, Xiaoyu,Su, Mingbo,Zhang, Xinwen,Li, Dan,Li, Honglin,Li, Shiliang,Zhao, Zhenjiang. "Design, Synthesis and SAR Studies of Novel and Potent Dipeptidyl Peptidase 4 Inhibitors". supporting information. p. 115 - 120. Retrieved 2020/12/28.
• 2、 Zhang, Jianwei,Wang, Jian. "Atropoenantioselective redox-neutral amination of biaryl compounds through borrowing hydrogen and dynamic kinetic resolution". supporting information. p. 465 - 469. Retrieved 2017/12/15.