2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

Base Information

• Chemical Name: 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
• CAS No.: 74901-69-2
• Molecular Formula: C6H4Cl2N2S
• Molecular Weight: 207.083
• Hs Code.: 2934999090
• Mol file: 74901-69-2.mol

Synonyms:2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

Chemical Property of 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

Chemical Property:

• Vapor Pressure: 0.000341mmHg at 25°C
• Refractive Index: 1.67
• Boiling Point: 329.4 °C at 760 mmHg
• PKA: -2.53±0.20(Predicted)
• Flash Point: 153 °C
• PSA: 51.08000
• Density: 1.613 g/cm³
• LogP: 2.43160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

There total 7 articles about 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6,7-dihydro-thieno[3,2-d]pyrimidine-2,4-diol (913581-92-7) → 2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine (74901-69-2)

Guidance literature:

With N,N-diethylaniline; trichlorophosphate; at 25 - 110 ℃; Inert atmosphere;

DOI:10.1021/acs.oprd.6b00104

Reference yield:

6,7-dihydrothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (913581-92-7) → 2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine (74901-69-2)

Guidance literature:

With P,P-dichlorophenylphosphine oxide; at 130 - 140 ℃; for 6h;

Reference yield:

3-ureido-4,5-dihydro-thiophene-2-carboxylic acid methyl ester (1196101-46-8) → 2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine (74901-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / 3 h / 85 °C / Large scale

2: N,N-diethylaniline; trichlorophosphate / 25 - 110 °C

With water; N,N-diethylaniline; sodium hydroxide; trichlorophosphate;

upstream raw materials:

6,7-dihydro-thieno[3,2-d]pyrimidine-2,4-diol

3-ureido-4,5-dihydro-thiophene-2-carboxylic acid methyl ester

dimethyl-3-thiaadipate

methyl tetrahydrothiophen-3-one-2-carboxylate

Downstream raw materials:

(S)-1-cyclopropyl-3-(4-(4-(3-methylmorpholino)-5,5-dioxido-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)phenyl)urea

Refernces

• 1、 -. "NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA". Paragraph 0079-0080. . Retrieved 2015/02/25.
• 2、 -. "SPECIFIC PDE4B-INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS". Page/Page column 43; 44. . Retrieved 2014/09/03.