Technology Process of (2R,3R,4S,5R,6S)-2-methyl-6-{[(2S)-6-methyl-2-(4-methylcyclohex-3-en-1-yl)hept-5-en-2-yl]oxy}tetrahydro-2H-pyran-3,4,5-triol
There total 6 articles about (2R,3R,4S,5R,6S)-2-methyl-6-{[(2S)-6-methyl-2-(4-methylcyclohex-3-en-1-yl)hept-5-en-2-yl]oxy}tetrahydro-2H-pyran-3,4,5-triol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate / dichloromethane / 16 h / 20 °C
2: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 2.5 h / -78 - 20 °C / Molecular sieve; Inert atmosphere
3: sodium hydroxide / water; methanol; tetrahydrofuran / 1.5 h / 20 °C
With
trimethylsilyl trifluoromethanesulfonate; caesium carbonate; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.bioorg.2019.102935
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogen bromide; acetic acid / dichloromethane / 3 h / 20 °C
2: silver carbonate; water / dichloromethane; acetone / 1 h / 20 °C
3: caesium carbonate / dichloromethane / 18 h / 20 °C
4: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 2 h / -78 °C / Molecular sieve
5: water; sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C
With
trimethylsilyl trifluoromethanesulfonate; water; hydrogen bromide; caesium carbonate; acetic acid; silver carbonate; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1248/cpb.c20-00834