1-Amino-1-deoxy-beta-D-galactose

Base Information

• Chemical Name: 1-Amino-1-deoxy-beta-D-galactose
• CAS No.: 74867-91-7
• Molecular Formula: C6H13NO5
• Molecular Weight: 179.17
• Hs Code.: 29329990
• European Community (EC) Number: 616-151-6
• DSSTox Substance ID: DTXSID501313609
• Nikkaji Number: J1.575.986K
• Mol file: 74867-91-7.mol

Synonyms:galactosylamine;1-Amino-1-deoxy-D-galactose;74867-91-7;1-Amino-1-deoxy-beta-D-galactose;beta-d-galactopyranosylamine;beta-D-Galactosylamine;D-Galactopyranosylamine;B-D-GALACTOPYRANOSYL AMINE;MFCD00047541;6318-23-6;b-D-Galactopyranosylamine;SCHEMBL2934015;WCWOEQFAYSXBRK-SVZMEOIVSA-N;DTXSID501313609;AMY41546;AKOS006312036;W-203349

Chemical Property of 1-Amino-1-deoxy-beta-D-galactose

Chemical Property:

• Appearance/Colour: white crystalline solid
• Vapor Pressure: 1.12E-08mmHg at 25°C
• Melting Point: 128-133 °C
• Refractive Index: 1.6
• Boiling Point: 416.4 °C at 760 mmHg
• Flash Point: 205.6 °C
• PSA: 116.17000
• Density: 1.563 g/cm³
• LogP: -2.55470
• Storage Temp.: 2-8°C
• XLogP3: -2.8
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 179.07937252
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

98%, ^*data from raw suppliers

1-Amino-1-deoxy-β-D-galactose ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C1C(C(C(C(O1)N)O)O)O)O
• Isomeric SMILES: C([C@@H]1[C@@H]([C@@H]([C@H](C(O1)N)O)O)O)O
• Uses: 1-Amino-1-Deoxy-Beta-D-Galactose, a galactose analogue, is used as a competitive inhibitor to help isolate, purify, identify, differentiate and characterize β-D-galactosidase(s) and galactose oxidase(s).

Technology Process of 1-Amino-1-deoxy-beta-D-galactose

There total 4 articles about 1-Amino-1-deoxy-beta-D-galactose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

D-Galactose (10257-28-0) → (3R,4S,5R,6R)-2-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (74867-91-7,50444-86-5)

Guidance literature:

With ammonia; acetic acid; In methanol; water; at 20 ℃; for 27.5h;

DOI:10.1021/acsmedchemlett.6b00427

Reference yield:

D-Mannose (530-26-7) → (3R,4S,5R,6R)-2-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (74867-91-7,50444-86-5)

Guidance literature:

With ammonia; In methanol; at 60 ℃; for 72h; Autoclave;

DOI:10.1016/j.bmcl.2019.126840

Reference yield:

D-Galactose (10257-28-0) + ammonium bicarbonate → (3R,4S,5R,6R)-2-amino-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (74867-91-7,50444-86-5) + Carbamic acid (3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl ester

Guidance literature:

With ammonia; In water; at 42 ℃; for 36h;

DOI:10.1081/CAR-100104862

upstream raw materials:

D-Galactose

D-Mannose

Downstream raw materials:

N-Tetradecyl-N-(D-galactopyranosyl)-amine

N-Tetradecyl-N-(D-galactopyranosyl)-oleamide

Refernces

• 1、 Doura, Tomohiro,Takahashi, Kazuaki,Ogra, Yasumitsu,Suzuki, Noriyuki. "Combretastatin A4-β-Galactosyl Conjugates for Ovarian Cancer Prodrug Monotherapy". supporting information. p. 211 - 214. Retrieved 2017/03/08.
• 2、 -. "Platinum complexes of polyhydroxylated alkylamines and 2-polyhydroxylated alkyl-1,2-diaminoethanes". . . Retrieved 2008/06/13.