Technology Process of 3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-isoindol-1-one
There total 6 articles about 3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-isoindol-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen; lithium hydroxide;
In
isopropyl alcohol;
at 60 ℃;
for 24h;
under 7500.75 Torr;
- Guidance literature:
-
N-(p-methoxyphenyl)benzamide;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 - 0 ℃;
for 0.6h;
Inert atmosphere;
N,N-dimethyl-formamide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
DOI:10.1002/jhet.1636
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dichloromethane / 0.5 h / 20 °C
2: acetic anhydride; sodium acetate / 90 °C
3: sodium tetrahydroborate / methanol / 1 h / Cooling with ice
With
sodium tetrahydroborate; sodium acetate; acetic anhydride;
In
methanol; dichloromethane;
DOI:10.3762/bjoc.10.81