Technology Process of 2(1H)-Pyridinone, 1-methyl-3-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
There total 5 articles about 2(1H)-Pyridinone, 1-methyl-3-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium acetate; XPhos;
palladium diacetate;
In
1,4-dioxane;
at 100 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate; tetra-(n-butyl)ammonium iodide / dimethyl sulfoxide / 120 °C
2: ammonium chloride; iron / ethanol; water / 3 h / 80 °C
3: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 0.5 h / 100 °C / Inert atmosphere; sealed tube
4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 3 h / Reflux; Inert atmosphere
With
potassium acetate; tetra-(n-butyl)ammonium iodide; iron; potassium carbonate; ammonium chloride; caesium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; ethanol; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium carbonate; tetra-(n-butyl)ammonium iodide / dimethyl sulfoxide / 120 °C
2: ammonium chloride; iron / ethanol; water / 3 h / 80 °C
3: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 0.5 h / 100 °C / Inert atmosphere; sealed tube
4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 3 h / Reflux; Inert atmosphere
With
potassium acetate; tetra-(n-butyl)ammonium iodide; iron; potassium carbonate; ammonium chloride; caesium carbonate;
tris-(dibenzylideneacetone)dipalladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
1,4-dioxane; ethanol; water; dimethyl sulfoxide;