Ethylene disalicylate

Base Information

• Chemical Name: Ethylene disalicylate
• CAS No.: 20210-97-3
• Molecular Formula: C16H14 O6
• Molecular Weight: 302.284
• Hs Code.: 2918290000
• European Community (EC) Number: 243-604-1
• UNII: MG4BE4A6U9
• DSSTox Substance ID: DTXSID30174061
• Nikkaji Number: J280.485I
• Wikidata: Q83044113
• Mol file: 20210-97-3.mol

Synonyms:Ethylene disalicylate;20210-97-3;2-(2-hydroxybenzoyl)oxyethyl 2-hydroxybenzoate;MG4BE4A6U9;EINECS 243-604-1;ethane-1,2-diyl bis(2-hydroxybenzoate);UNII-MG4BE4A6U9;Salicylic acid glycol ester;SCHEMBL6063013;DTXSID30174061;2-[(2-Hydroxybenzoyl)oxy]ethyl salicylate;2-(2-HYDROXYBENZOYL)OXYETHYL2-HYDROXYBENZOATE

Chemical Property of Ethylene disalicylate

Chemical Property:

• Vapor Pressure: 7.91E-09mmHg at 25°C
• Boiling Point: 453.1°C at 760 mmHg
• Flash Point: 166.4°C
• PSA: 93.06000
• Density: 1.355g/cm³
• LogP: 2.11160
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 302.07903816
• Heavy Atom Count: 22
• Complexity: 347

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)OCCOC(=O)C2=CC=CC=C2O)O

Technology Process of Ethylene disalicylate

There total 12 articles about Ethylene disalicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

ethylene glycol (107-21-1) + salicylic acid (69-72-7,25496-36-0,8052-31-1) → ethane-1,2-diyl bis(2-hydroxybenzoate) (20210-97-3)

Guidance literature:

sulfuric acid; Heating;

Reference yield: 23.0%

ethylene glycol (107-21-1) + methyl salicylate (119-36-8,8024-54-2) → ethane-1,2-diyl bis(2-hydroxybenzoate) (20210-97-3)

Guidance literature:

With sodium; at 150 ℃; for 2h;

Reference yield: 22.0%

ethylene glycol (107-21-1) + methyl salicylate (119-36-8,8024-54-2) → 2-hydroxyethyl salicylate (87-28-5) + ethane-1,2-diyl bis(2-hydroxybenzoate) (20210-97-3)

Guidance literature:

With sodium; at 100 - 160 ℃; for 0.25h; Microwave irradiation;

upstream raw materials:

2-hydroxyethyl salicylate

ethylene glycol

salicylic acid

salicyloyl chloride

Downstream raw materials:

5-nitro-1,2-bis(salicyloyloxy)ethane

3',5''-dinitro-1,2-bis(salicyloyloxy)ethane

5',5''-dinitro-1,2-bis(salicyloyloxy)ethane

Refernces

• 1、 Djurendic, Evgenija,Vujaskovic, Sanja Dojcinovic,Sakac, Marija,Ajdukovic, Jovana,Gakovic, Andrea,Kojic, Vesna,Bogdanovic, Gordana,Klisuric, Olivera,Gasi, Katarina Penov. "Synthesis and biological evaluation of some new 2-oxazoline and salicylic acid derivatives". experimental part. . Retrieved 2011/05/11.
• 2、 Mikhant'eva, O. N.,Romanova, V. S.,Mikhant'ev, V. B.. "SYNTHESIS OF MONO- AND DIESTERS OF ETHYLENE GLYCOL AND MONOCARBOXYLIC ACIDS". . p. 990 - 993. Retrieved 2007/10/02.