5-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

Base Information

• Chemical Name: 5-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
• CAS No.: 799274-07-0
• Molecular Formula: C₉H₁₀FN*ClH
• Molecular Weight: 187.644
• Hs Code.: 2933499090
• Mol file: 799274-07-0.mol

Synonyms:5-Fluoro-1,2,3,4-tetrahydroisoquinolinehydrochloride;Isoquinoline,5-fluoro-1,2,3,4-tetrahydro-, hydrochloride (9CI);

Chemical Property of 5-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

Chemical Property:

• PSA: 12.03000
• LogP: 2.60220
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-1,2,3,4-tetrahydroisoquinolineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE

There total 4 articles about 5-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[2-(2-fluorophenyl)ethyl]amine (52721-69-4) → 5-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride (799274-07-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: acetic acid; sulfuric acid / 15 h / 0 - 30 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / 90 °C

With hydrogenchloride; sulfuric acid; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane;

Reference yield:

2-(tert-butoxycarbonyl)-5-fluoro-1,2,3,4-tetrahydroisoquinoline (138350-94-4) → 5-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride (799274-07-0)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 3h;

Reference yield:

2,2,2-trifluoro-1-(5-fluoro-3.4-dihydroisoquinolin-2(1H)-yl)ethan-1-one → 5-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride (799274-07-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 90 ℃; for 2h;

upstream raw materials:

2-(tert-butoxycarbonyl)-5-fluoro-1,2,3,4-tetrahydroisoquinoline

[2-(2-fluorophenyl)ethyl]amine

Refernces

• 1、 -. "NOVEL TETRAHYDROISOQUINOLINES AND TERAHYDRONAPHTHYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION". Page/Page column 60. . Retrieved 2018/05/24.