N²-benzoyl-O⁶-methyldeoxyguanosine

Base Information

• Chemical Name: N²-benzoyl-O⁶-methyldeoxyguanosine
• CAS No.: 80228-07-5
• Molecular Formula: C₁₈H₁₉N₅O₅
• Molecular Weight: 385.379
• Mol file: 80228-07-5.mol

Synonyms:N²-benzoyl-O⁶-methyldeoxyguanosine

Chemical Property of N²-benzoyl-O⁶-methyldeoxyguanosine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N²-benzoyl-O⁶-methyldeoxyguanosine

There total 2 articles about N²-benzoyl-O⁶-methyldeoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N2,O3,O5-tribenzoyl-O6-methyldeoxyguanosine (80228-06-4) → N2-benzoyl-O6-methyldeoxyguanosine (80228-07-5)

Guidance literature:

With sodium hydroxide; In pyridine; ethanol; for 0.0833333h; Ambient temperature;

DOI:10.1021/ja00368a023

Reference yield:

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine (964-21-6,52225-08-8) → N2-benzoyl-O6-methyldeoxyguanosine (80228-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / pyridine / 1.) 0 deg C, 0.5 h, 2.) room temperature, 2 h

2: 77 percent / 2N NaOH / pyridine; ethanol / 0.08 h / Ambient temperature

With sodium hydroxide; In pyridine; ethanol;

DOI:10.1021/ja00368a023

Reference yield: 68.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N2-benzoyl-O6-methyldeoxyguanosine (80228-07-5) → N-benzoyl-5'-dimethoxytrityl-O6-methyldeoxyguanosine (80228-08-6)

Guidance literature:

In pyridine; for 18h;

DOI:10.1021/ja00368a023

upstream raw materials:

N²,O³,O⁵-tribenzoyl-O⁶-methyldeoxyguanosine

2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-methoxypurine

Downstream raw materials:

N-benzoyl-5'-dimethoxytrityl-O⁶-methyldeoxyguanosine

Refernces