Technology Process of 4-Pentenenitrile,5-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-hydroxy-2-methylene-,(3S,4E)-(9CI)
There total 3 articles about 4-Pentenenitrile,5-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-hydroxy-2-methylene-,(3S,4E)-(9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; Cumene hydroperoxide;
In
dichloromethane;
at -20 ℃;
DOI:10.1016/j.tetlet.2004.08.166
- Guidance literature:
-
Multi-step reaction with 3 steps
1: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 °C
2: 55 percent / DABCO / dimethylformamide / 48 h / 20 °C
3: 35 percent / (+)-DIPT; Ti-(O-i-Pr)4; Cumene hydroperoxide / CH2Cl2 / -20 °C
With
1,4-diaza-bicyclo[2.2.2]octane; titanium(IV) isopropylate; oxalyl dichloride; L-(+)-diisopropyl tartrate; Cumene hydroperoxide; dimethyl sulfoxide; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
2: Baylis-Hillman reaction / 3: Sharpless asymmetric epoxidation;
DOI:10.1016/j.tetlet.2004.08.166
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 55 percent / DABCO / dimethylformamide / 48 h / 20 °C
2: 35 percent / (+)-DIPT; Ti-(O-i-Pr)4; Cumene hydroperoxide / CH2Cl2 / -20 °C
With
1,4-diaza-bicyclo[2.2.2]octane; titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; Cumene hydroperoxide;
In
dichloromethane; N,N-dimethyl-formamide;
1: Baylis-Hillman reaction / 2: Sharpless asymmetric epoxidation;
DOI:10.1016/j.tetlet.2004.08.166