2-(4-chlorophenyl)-3-methylquinoxaline

Base Information

• Chemical Name: 2-(4-chlorophenyl)-3-methylquinoxaline
• CAS No.: 70071-22-6
• Molecular Formula: C₁₅H₁₁ClN₂
• Molecular Weight: 254.719
• Mol file: 70071-22-6.mol

Synonyms:2-(4-chlorophenyl)-3-methylquinoxaline

Chemical Property of 2-(4-chlorophenyl)-3-methylquinoxaline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chlorophenyl)-3-methylquinoxaline

There total 7 articles about 2-(4-chlorophenyl)-3-methylquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-chloro-4-(2-nitropropenyl)benzene (710-20-3) + 1,2-diamino-benzene (95-54-5) → 2-(4-chlorophenyl)-3-methylquinoxaline (70071-22-6)

Guidance literature:

With silica gel; In tetrahydrofuran; at 50 ℃; for 5h; chemoselective reaction;

DOI:10.1016/j.tetlet.2014.08.022

Reference yield: 92.0%

1-(4-chlorophenyl)-2-(hydroxyimino)propan-1-one (56472-72-1) + 1,2-diamino-benzene (95-54-5) → 2-(4-chlorophenyl)-3-methylquinoxaline (70071-22-6)

Guidance literature:

at 140 ℃; for 0.125h; Microwave irradiation; neat (no solvent);

DOI:10.1016/j.tetlet.2010.11.116

Reference yield: 54.0%

4'-chloropropiophenone (6285-05-8) + 1,2-diamino-benzene (95-54-5) → 2-(4-chlorophenyl)-3-methylquinoxaline (70071-22-6)

Guidance literature:

With potassium hydroxide; In various solvent(s); at 60 ℃; for 60h;

DOI:10.1016/j.tetlet.2007.05.044

upstream raw materials:

4'-chloropropiophenone

1,2-diamino-benzene

1-(4-chlorophenyl)-2-(hydroxyimino)propan-1-one

1-chloro-4-(2-nitropropenyl)benzene

Downstream raw materials:

2-(4-chlorophenyl)-3-vinylquinoxaline

2-(2-benzo[1,3]dioxol-5-yl-vinyl)-3-(4-chloro-phenyl)-quinoxaline

Refernces

• 1、 Wu, Degui,Zhang, Jian,Cui, Jianhai,Zhang, Wei,Liu, Yunkui. "AgNO2-mediated direct nitration of the quinoxaline tertiary benzylic C-H bond and direct conversion of 2-methyl quinoxalines into related nitriles". supporting information. p. 10857 - 10860. Retrieved 2014/09/30.
• 2、 Chen, Yongxin,Li, Kangning,Zhao, Mingming,Li, Yuanjiao,Chen, Baohua. "Cu(II)-catalyzed synthesis of quinoxalines from o-phenylenediamines and nitroolefins". supporting information. p. 1627 - 1630. Retrieved 2013/03/28.