3-allyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 3-allyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one
• CAS No.: 1621967-97-2
• Molecular Formula: C₁₅H₁₂N₂OS
• Molecular Weight: 268.339
• Mol file: 1621967-97-2.mol

Synonyms:3-allyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one

Chemical Property of 3-allyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-allyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one

There total 5 articles about 3-allyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

allylammonium chloride (10017-11-5,110507-15-8,71550-12-4) + methyl 3-amino-4-phenyl-2-thiophenecarboxylate (82437-64-7) + orthoformic acid triethyl ester (122-51-0) → 3-allyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one (1621967-97-2)

Guidance literature:

With acetic acid; at 160 ℃; Inert atmosphere; Autoclave;

DOI:10.1002/bkcs.10283

Reference yield: 57.5%

→ 3-allyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one (1621967-97-2)

Guidance literature:

With acetic acid; orthoformic acid triethyl ester; at 160 ℃; for 18h;

Reference yield:

phenylacetonitrile (140-29-4) → 3-allyl-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one (1621967-97-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.2: 40 °C / Inert atmosphere

3.1: sodium methylate / methanol / 65 °C / Inert atmosphere

4.1: acetic acid / 160 °C / Inert atmosphere; Autoclave

With sodium methylate; sodium hydride; acetic acid; In tetrahydrofuran; methanol;

DOI:10.1002/bkcs.10283

upstream raw materials:

allylammonium chloride

methyl 3-amino-4-phenyl-2-thiophenecarboxylate

orthoformic acid triethyl ester

phenylacetonitrile

Refernces

• 1、 -. "THIENOPYRIMIDINONE DERIVATIVES AS mGluR1 ANTAGONISTS". Paragraph 0201; 0202; 0356; 0357. . Retrieved 2014/08/19.