4-methoxyphenyl diethylcarbamate

Base Information

• Chemical Name: 4-methoxyphenyl diethylcarbamate
• CAS No.: 85630-18-8
• Molecular Formula: C12H17 N O3
• Molecular Weight: 223.272
• Mol file: 85630-18-8.mol

Synonyms:Carbamicacid, diethyl-, 4-methoxyphenyl ester (9CI); 4-Methoxyphenyl diethylcarbamate;NSC 221234

Chemical Property of 4-methoxyphenyl diethylcarbamate

Chemical Property:

• Vapor Pressure: 0.000409mmHg at 25°C
• Boiling Point: 316.5°C at 760 mmHg
• Flash Point: 145.2°C
• Density: 1.074g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methoxyphenyl diethylcarbamate

There total 2 articles about 4-methoxyphenyl diethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,N-diethylcarbamyl chloride (88-10-8) + 4-methoxy-phenol (150-76-5) → N,N-diethyl-O-(4-methoxyphenyl)carbamate (85630-18-8)

Guidance literature:

4-methoxy-phenol; With sodium hydride; In 1,2-dimethoxyethane; mineral oil; at 0 - 23 ℃; for 0.166667h;

N,N-diethylcarbamyl chloride; In 1,2-dimethoxyethane; mineral oil; at 23 ℃; for 11h;

DOI:10.1021/ja906477r

Reference yield: 39.0%

carbon dioxide (124-38-9,18923-20-1) + 4-methoxyphenylboronic acid (5720-07-0) + diethylamine (109-89-7) → N,N-diethyl-O-(4-methoxyphenyl)carbamate (85630-18-8)

Guidance literature:

With pyridine; copper(I) oxide; boron trifluoride diethyl etherate; oxygen; In dichloromethane; at 80 ℃; for 24h; under 30003 Torr; Autoclave;

DOI:10.1039/c6gc03465a

Reference yield: 98.0%

N,N-diethyl-O-(4-methoxyphenyl)carbamate (85630-18-8) → 4-methoxy-phenol (150-76-5)

Guidance literature:

With zirconocene dichloride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol401547d

upstream raw materials:

N,N-diethylcarbamyl chloride

4-methoxy-phenol

carbon dioxide

4-methoxyphenylboronic acid

Downstream raw materials:

O-(2-trimethylsilyl-4-methoxy)phenyl N,N-diethylcarbamate

O-(2-carboxy-4-methoxy)phenyl N,N-diethylcarbamate

N,N-diethyl-2-hydroxy-5-methoxybenzamide

2-hydroxy-5-methoxybenzaldehyde

Refernces

• 1、 Geng, Shasha,Zhang, Juan,Chen, Shuo,Liu, Zhengli,Zeng, Xiaoqin,He, Yun,Feng, Zhang. "Development and Mechanistic Studies of Iron-Catalyzed Construction of Csp2-B Bonds via C-O Bond Activation". supporting information. p. 5582 - 5588. Retrieved 2020/07/08.
• 2、 Feberero, Claudia,Lopez, Carlos Silva,Sanz, Roberto,Sedano, Carlos,Suarez-Pantiga, Samuel. "Experimental and computational study of the 1,5-o → n carbamoyl snieckus-fries-type rearrangement". . p. 12561 - 12578. Retrieved 2020/11/09.