Technology Process of (R)-2-methyl-2-[2'-(phenylmethoxy)ethyl]oxirane
There total 9 articles about (R)-2-methyl-2-[2'-(phenylmethoxy)ethyl]oxirane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1071/CH99091
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 10.02 g / CH2Cl2; ethanol / 0.5 h
2.1: 84 percent / LiAlH4 / tetrahydrofuran / 18 h / Heating
3.1: 82 percent / p-toluenesulfonic acid / 24 h / 20 °C
4.1: NaH / tetrahydrofuran
4.2: 91 percent / tetrabutylammonium iodide / tetrahydrofuran / 24 h
5.1: 92 percent / aq. H2SO4 / tetrahydrofuran / 4 h / 40 °C
6.1: 91 percent / Et3N / CH2Cl2 / 0.17 h / -10 °C
7.1: 94 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / CH2Cl2 / 1 h / 20 °C
With
lithium aluminium tetrahydride; sulfuric acid; sodium hydride; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane;
1.1: Esterification / 2.1: Reduction / 3.1: cyclocondensation / 4.1: deprotonation / 4.2: benzylation / 5.1: Hydrolysis / 6.1: Esterification / 7.1: cyclocondensation;
DOI:10.1071/CH99091
