6-bromo-2,3-dihydroxybenzaldehyde

Base Information

• Chemical Name: 6-bromo-2,3-dihydroxybenzaldehyde
• CAS No.: 83983-71-5
• Molecular Formula: C₇H₅BrO₃
• Molecular Weight: 217.019
• Mol file: 83983-71-5.mol

Synonyms:6-bromo-2,3-dihydroxybenzaldehyde

Chemical Property of 6-bromo-2,3-dihydroxybenzaldehyde

Chemical Property:

Purity/Quality:

6-BROMO-2,3-DIHYDROXYBENZALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-bromo-2,3-dihydroxybenzaldehyde

There total 8 articles about 6-bromo-2,3-dihydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

6-bromo-3-ethoxy-2-hydroxybenzaldehyde (20035-45-4) → 6-bromo-2,3-dihydroxybenzaldehyde (83983-71-5)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃;

Reference yield: 95.0%

6-bromo-2-hydroxy-3-methoxybenzaldehyde (20035-41-0) → 6-bromo-2,3-dihydroxybenzaldehyde (83983-71-5)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c4ob01470g

Reference yield:

3-methoxy-2-hydroxybenzaldehyde (148-53-8) → 6-bromo-2,3-dihydroxybenzaldehyde (83983-71-5)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap / 20 °C / Inert atmosphere

2: potassium bromide; bromine / water / 20 °C

3: sodium hydrogencarbonate; water / methanol / 2 h / 20 °C

4: boron tribromide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With dmap; water; bromine; boron tribromide; sodium hydrogencarbonate; potassium bromide; In methanol; dichloromethane; water;

upstream raw materials:

6-bromo-2-hydroxy-3-methoxybenzaldehyde

6-bromo-3-ethoxy-2-hydroxybenzaldehyde

1,1-diacetoxy-1-(2-acetoxy-3-methoxyphenyl)methane

6-Brom-2-acetoxy-3-methoxy-benzaldehyddiacetat

Downstream raw materials:

6-bromo-2,3-dimethoxybenzaldehyde

dihydrosanguinarine

sanguinarine chloride

norsanguinarine

Refernces

• 1、 Wang, Bo,Wang, Liping,Peng, Ying,Pang, Yiying,Xiao, Hesheng,Wang, Xiaoji,Huang, Shuangping. "The first total synthesis of (±)-methyl salvianolate A using a convergent strategy". . . Retrieved 2019/03/19.
• 2、 -. "New synthesis method of natural product Salvianolic Acid F". Paragraph 0014; 0031; 0032; 0036. . Retrieved 2018/01/04.