p-Tolyl phosphorodichloridate

Base Information

• Chemical Name: p-Tolyl phosphorodichloridate
• CAS No.: 878-17-1
• Molecular Formula: C7H7Cl2O2P
• Molecular Weight: 225.011
• Hs Code.: 2931900090
• Mol file: 878-17-1.mol

Synonyms:Phosphorodichloridicacid, p-tolyl ester (8CI);p-Cresol, phosphorodichloridate (7CI);p-Tolylphosphorodichloridate (6CI);4-Methylphenyl dichlorophosphinate;4-Methylphenylphosphorodichloridate;4-Tolyl dichlorophosphate;4-Tolylphosphorodichloridate;NSC 66506;Phosphoroyl dichloride p-tolyl ester;p-Methylphenyl phosphorodichloridate;p-Tolyl dichlorophosphate;

Chemical Property of p-Tolyl phosphorodichloridate

Chemical Property:

• Vapor Pressure: 0.0153mmHg at 25°C
• Refractive Index: 1.533
• Boiling Point: 265.2 °C at 760 mmHg
• Flash Point: 129 °C
• PSA: 36.11000
• Density: 1.405g/cm³
• LogP: 3.95950

Purity/Quality:

97% ^*data from raw suppliers

4-TOLYL PHOSPHORODICHLORIDATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of p-Tolyl phosphorodichloridate

There total 4 articles about p-Tolyl phosphorodichloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

p-cresol (106-44-5) → 4-methylphenyl phosphorodichloridate (878-17-1)

Guidance literature:

With triethylamine; trichlorophosphate; In diethyl ether; 1.) from 0 deg C to RT, 15 h, 2.) reflux, 2h;

DOI:10.1021/jm00060a013

Reference yield: 72.0%

→ 4-methylphenyl phosphorodichloridate (878-17-1)

Guidance literature:

Reference yield:

p-cresol (106-44-5) → dicresyl phosphorochloridate (6630-15-5) + 4-methylphenyl phosphorodichloridate (878-17-1)

Guidance literature:

With aluminium trichloride; trichlorophosphate;

DOI:10.1021/ja01536a052

upstream raw materials:

p-cresol

trichlorophosphate

Downstream raw materials:

phosphoric acid mono-p-tolyl ester

2-(p-methylphenoxy)-1,3,6,2-dioxaselenaphosphocane 2-oxide

hydrogenchloride

Refernces

• 1、 -. "PRODRUGS OF THE TYROSINE KINASE INHIBITOR FOR TREATING CANCER". Paragraph 00117-00118. . Retrieved 2021/03/05.
• 2、 Malik, Payal,Chakraborty, Debashis,Ramkumar, Venkatachalam. "New phosphoroamidate compounds: Synthesis, structural characterization and studies on ZnCl2 assisted hydrolysis of the P-N bond". experimental part. p. 2142 - 2148. Retrieved 2011/01/08.