Carbamic acid, (4-hydroxy-1-methylcyclohexyl)-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, (4-hydroxy-1-methylcyclohexyl)-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 792913-83-8
• Molecular Formula: C12H23 N O3
• Molecular Weight: 229.32
• Hs Code.: 2924299090
• Mol file: 792913-83-8.mol

Synonyms:tert-Butyl(4-hydroxy-1-methylcyclohexyl)carbamate

Chemical Property of Carbamic acid, (4-hydroxy-1-methylcyclohexyl)-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• PSA: 62.05000
• LogP: 2.40910
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl N-(4-hydroxy-1-methylcyclohexyl)carbamate 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, (4-hydroxy-1-methylcyclohexyl)-, 1,1-dimethylethyl ester (9CI)

There total 7 articles about Carbamic acid, (4-hydroxy-1-methylcyclohexyl)-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C21H43NO3Si (1342811-04-4) → tert-butyl N-(4-hydroxy-1-methylcyclohexyl)carbamate (792913-83-8,412293-61-9,412293-62-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile; at 20 ℃;

Reference yield: 85.0%

tert-butyl N-(1-methyl-4-oxo-cyclohexyl)carbamate (412293-43-7) → tert-butyl N-(4-hydroxy-1-methylcyclohexyl)carbamate (792913-83-8,412293-61-9,412293-62-0)

Guidance literature:

With methanol; sodium tetrahydroborate; at 20 ℃; for 2h;

Reference yield:

4-hydroxycyclohexyl carboxylic acid ethyl ester (3618-04-0,75877-66-6,17159-80-7) → tert-butyl N-(4-hydroxy-1-methylcyclohexyl)carbamate (792913-83-8,412293-61-9,412293-62-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 70 °C

2.2: pH 3 - 4

3.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - 60 °C

3.2: -78 - 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 115 °C

5.1: ISOPROPYLAMIDE / 20 °C

6.1: tetrabutyl ammonium fluoride / acetonitrile; tetrahydrofuran / 20 °C

With 1H-imidazole; n-butyllithium; diphenyl phosphoryl azide; tetrabutyl ammonium fluoride; water; triethylamine; diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; hexane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

tert-butyl N-(1-methyl-4-oxo-cyclohexyl)carbamate

4-hydroxycyclohexyl carboxylic acid ethyl ester

ethyl 4-triisopropylsilyloxycyclohexylcarboxylate

C₁₆H₃₂O₃Si

Downstream raw materials:

tert-butyl N-(1-methyl-4-oxo-cyclohexyl)carbamate

C₁₇H₂₅BrN₄O₂

4-amino-4-methylcyclohexan-1-ol hydrochloride

tert-butyl 4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]-1-methylcyclohexylcarbamate

Refernces

• 1、 -. "Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins". . . Retrieved 2011/11/30.