1-nitro-2-(1-phenyl-1-propen-1-yl)benzene

Base Information

• Chemical Name: 1-nitro-2-(1-phenyl-1-propen-1-yl)benzene
• CAS No.: 1310481-67-4
• Molecular Formula: C₁₅H₁₃NO₂
• Molecular Weight: 239.274
• Mol file: 1310481-67-4.mol

Synonyms:1-nitro-2-(1-phenyl-1-propen-1-yl)benzene

Chemical Property of 1-nitro-2-(1-phenyl-1-propen-1-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-nitro-2-(1-phenyl-1-propen-1-yl)benzene

There total 3 articles about 1-nitro-2-(1-phenyl-1-propen-1-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-nitrophenyl bromide (577-19-5) + propiophenone N-tosylhydrazone (17336-66-2) → 2-methyl-3-phenyl-1H-indole (4757-69-1) + 1-nitro-2-(1-phenyl-1-propen-1-yl)benzene (1310481-67-4)

Guidance literature:

2-nitrophenyl bromide; propiophenone N-tosylhydrazone; With bis-triphenylphosphine-palladium(II) chloride; lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 2h; Inert atmosphere;

With carbon monoxide; 1,3-bis-(diphenylphosphino)propane; In 1,4-dioxane; at 140 ℃; for 72h; under 4560.31 Torr; Reagent/catalyst; Temperature; Inert atmosphere;

DOI:10.1016/j.tet.2021.132331

Reference yield: 90.0%

2-nitrophenyl bromide (577-19-5) + propiophenone N-tosylhydrazone (17336-66-2) → 1-nitro-2-(1-phenyl-1-propen-1-yl)benzene (1310481-67-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tet.2021.132331

Reference yield: 84.0%

1-(tributylstannyl)-1-phenyl-1-propene (125405-88-1,112713-91-4) + o-nitroiodobenzene (609-73-4) → 1-nitro-2-(1-phenyl-1-propen-1-yl)benzene (1310481-67-4)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; dichloro bis(acetonitrile) palladium(II); copper(l) iodide; triphenyl-arsane; at 80 ℃; for 72h; Inert atmosphere;

DOI:10.1016/j.tet.2011.03.029

upstream raw materials:

1-(tributylstannyl)-1-phenyl-1-propene

o-nitroiodobenzene

2-nitrophenyl bromide

propiophenone N-tosylhydrazone

Downstream raw materials:

4-phenylquinoline

2-methyl-3-phenyl-1H-indole

Refernces

• 1、 Banini, Serge R.,Turner, Michael R.,Cummings, Matthew M.,S?derberg, Bj?rn C.G.. "A base-modulated chemoselective synthesis of 3-cyanoindoles or 4-cyanoquinolines using a palladium-catalyzed N-heterocyclization". experimental part. p. 3603 - 3611. Retrieved 2011/06/21.