Technology Process of 4-Pyridinecarboxylicacid,1,2,3,6-tetrahydro-,methylester(9CI)
There total 7 articles about 4-Pyridinecarboxylicacid,1,2,3,6-tetrahydro-,methylester(9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 3h;
- Guidance literature:
-
With
triphenylborane; diphenylsilane; diphenylamine;
In
toluene;
at 110 ℃;
for 24h;
chemoselective reaction;
Glovebox;
Inert atmosphere;
DOI:10.1002/anie.201702304
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 2-(3,5-bis(trifluoromethyl)phenyl)phosphino-2′,4′,6′-triisopropylbiphenyl; palladium diacetate; bis(2-phenylpyridinato)(2,2'-bipyridine)iridium(III) hexafluorophosphate; caesium carbonate; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 2 h / 20 °C / 760.05 Torr / Irradiation
2: diethyl ether; methanol / 0.5 h / 0 °C
With
bis(2-phenylpyridinato)(2,2'-bipyridine)iridium(III) hexafluorophosphate; 2-(3,5-bis(trifluoromethyl)phenyl)phosphino-2′,4′,6′-triisopropylbiphenyl; tetrabutylammomium bromide; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine;
In
methanol; diethyl ether; N,N-dimethyl acetamide;
DOI:10.1021/acs.orglett.9b01340