N-Benzyliden-2-hydroxy-1-propanamin

Base Information

• Chemical Name: N-Benzyliden-2-hydroxy-1-propanamin
• CAS No.: 124948-53-4
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Mol file: 124948-53-4.mol

Synonyms:N-Benzyliden-2-hydroxy-1-propanamin

Chemical Property of N-Benzyliden-2-hydroxy-1-propanamin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Benzyliden-2-hydroxy-1-propanamin

There total 3 articles about N-Benzyliden-2-hydroxy-1-propanamin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Amino-1-propanol (6168-72-5) + benzaldehyde (100-52-7) → N-Benzyliden-2-hydroxy-1-propanamin (124948-53-4)

Guidance literature:

With 3 A molecular sieve; for 8h; Ambient temperature;

DOI:10.1016/0040-4020(95)00321-X

Reference yield: 87.0%

benzaldehyde (100-52-7) + methyloxirane (75-56-9,16033-71-9) → N-Benzyliden-2-hydroxy-1-propanamin (124948-53-4)

Guidance literature:

With ammonia; In water; at 60 ℃; regioselective reaction;

DOI:10.1021/jo102455q

Reference yield:

(E,E)-1,3,5-triphenyl-2,4-diazapenta-1,4-diene (92-29-5,73311-46-3) → N-Benzyliden-2-hydroxy-1-propanamin (124948-53-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-bromo-butane / water / 60 °C

2: ammonia / water / 60 °C

With 1-bromo-butane; ammonia; In water;

DOI:10.1021/jo102455q

upstream raw materials:

2-Amino-1-propanol

benzaldehyde

(E,E)-1,3,5-triphenyl-2,4-diazapenta-1,4-diene

methyloxirane

Downstream raw materials:

N-Benzyliden-2-hydroxy-1-propanamin-N-oxid

2-[(E)-benzylideneamino]-1-phenylethan-1-ol

2-Benzylidenamino-2-phenylaethanol

(2Z,NE)-N-benzylidenebut-2-en-1-amine

Refernces

• 1、 Huang, Jing-Mei,Zhang, Jue-Fei,Dong, Yi,Gong, Wen. "An effective method to prepare imines from aldehyde, bromide/epoxide, and aqueous ammonia". . p. 3511 - 3514. Retrieved 2011/06/22.