trans-1,4-cyclohexylenedimethylene diacetate

Base Information

• Chemical Name: trans-1,4-cyclohexylenedimethylene diacetate
• CAS No.: 10412-78-9
• Molecular Formula: C₁₂H₂₀O₄
• Molecular Weight: 228.288
• Mol file: 10412-78-9.mol

Synonyms:trans-1,4-cyclohexylenedimethylene diacetate

Chemical Property of trans-1,4-cyclohexylenedimethylene diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-1,4-cyclohexylenedimethylene diacetate

There total 6 articles about trans-1,4-cyclohexylenedimethylene diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Isopropenyl acetate (108-22-5) + trans-1,4-Cyclohexanedimethanol (3236-48-4) → trans-1,4-cyclohexylenedimethylene diacetate (10412-78-9) + di-isopropenyl trans-1,4-cyclohexanedimethanol ether + C13H22O3

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; sodium carbonate; In toluene; at 100 ℃; for 6h; Inert atmosphere;

Reference yield: 15.0%

vinyl acetate (108-05-4,9003-20-7) + bis-1,4-(hydroxymethyl)cyclohexane (105-08-8) → (1s,4s)-cyclohexane-1,4-diyldimethanol (3236-47-3) + trans-1,4-cyclohexylenedimethylene diacetate (10412-78-9) + cis-4-(hydroxymethyl)cyclohexylmethyl acetate + (1R,4S)-cyclohexane-1,4-dimethanol diacetate

Guidance literature:

In various solvent(s); for 48h; Further byproducts given. Yields of byproduct given; Ambient temperature; lipase PS (Pseudomonas sp.) on Celite;

DOI:10.1248/cpb.43.529

Reference yield:

trans-1,4-bis-methanesulfonyloxymethyl-cyclohexane (115506-09-7,35541-77-6) → trans-1,4-cyclohexylenedimethylene diacetate (10412-78-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous KOH-solution

2: pyridine

With pyridine; potassium hydroxide;

DOI:10.1039/jr9530000399

upstream raw materials:

trans-1,4-Cyclohexanedimethanol

acetic anhydride

vinyl acetate

bis-1,4-(hydroxymethyl)cyclohexane

Downstream raw materials:

trans-4-(hydroxymethyl)cyclohexylmethyl 4-methylbenzenesulfonate

trans-4-(carbazole-9-yl)methylcyclohexylmethanol

trans-1,4-Cyclohexanedimethanol

Refernces