1,1,2,2-tetrafluoroethyl phenyl sulfoxide

Base Information

• Chemical Name: 1,1,2,2-tetrafluoroethyl phenyl sulfoxide
• CAS No.: 27605-43-2
• Molecular Formula: C₈H₆F₄O₂S
• Molecular Weight: 242.194
• Mol file: 27605-43-2.mol

Synonyms:1,1,2,2-tetrafluoroethyl phenyl sulfoxide

Chemical Property of 1,1,2,2-tetrafluoroethyl phenyl sulfoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1,2,2-tetrafluoroethyl phenyl sulfoxide

There total 33 articles about 1,1,2,2-tetrafluoroethyl phenyl sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,1,2,2-tetrafluoroethyl phenyl sulfide (403-58-7) → 1,1,2,2-tetrafluoroethyl phenyl sulfoxide (27605-43-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 26h;

DOI:10.1016/j.jfluchem.2014.10.019

Reference yield: 72.0%

trimethyl(1,1,2,2-tetrafluoro-2-(phenylsulfonyl)ethyl)silane + benzaldehyde (100-52-7) → 1,1,2,2-tetrafluoroethyl phenyl sulfoxide (27605-43-2) + 2,2,3,3-tetrafluoro-1-phenyl-3-(phenylsulfonyl)propan-1-ol

Guidance literature:

trimethyl(1,1,2,2-tetrafluoro-2-(phenylsulfonyl)ethyl)silane; benzaldehyde; With cesium fluoride; In N,N-dimethyl-formamide; at -50 ℃; Inert atmosphere; Schlenk technique;

With hydrogenchloride; water; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature;

DOI:10.1016/j.jfluchem.2014.10.019

Reference yield: 71.0%

trimethyl(1,1,2,2-tetrafluoro-2-(phenylsulfonyl)ethyl)silane + 4-bromo-benzaldehyde (1122-91-4) → 1,1,2,2-tetrafluoroethyl phenyl sulfoxide (27605-43-2) + 2,2,3,3-tetrafluoro-1-(4-bromophenyl)-3-(phenylsulfonyl)propan-1-ol

Guidance literature:

trimethyl(1,1,2,2-tetrafluoro-2-(phenylsulfonyl)ethyl)silane; 4-bromo-benzaldehyde; With cesium fluoride; In N,N-dimethyl-formamide; at -50 ℃; Inert atmosphere; Schlenk technique;

With hydrogenchloride; water; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1016/j.jfluchem.2014.10.019

upstream raw materials:

1,1,2,2-tetrafluoroethyl phenyl sulfide

trimethyl(1,1,2,2-tetrafluoro-2-(phenylsulfanyl)ethyl)silane

benzaldehyde

4-chlorobenzaldehyde

Downstream raw materials:

2,2,3,3-tetrafluoro-1-(4-chlorophenyl)propan-1-ol

2,2,3,3-tetrafluoro-1-(4-methoxyphenyl)propan-1-ol

1,1,2,2-tetrafluoro-5-phenylpentan-3-ol

1,1,2,2-tetrafluoroethane

Refernces

• 1、 Toulgoat, Fabien,Langlois, Bernard R.,Medebielle, Maurice,Sanchez, Jean-Yves. "An efficient preparation of new sulfonyl fluorides and lithium sulfonates". . p. 9046 - 9052. Retrieved 2008/03/27.