Technology Process of tert-butyl (3R,4R)-3-azido-4-(benzyloxy)azepane-1-carboxylate
There total 33 articles about tert-butyl (3R,4R)-3-azido-4-(benzyloxy)azepane-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran;
at 25 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1039/c3ob40391b
- Guidance literature:
-
trifluoroacetic anhydride; tert-butyl (3S,4R)-4-(benzyloxy)-3-hydroxyazepane-1-carboxylate;
With
2,6-dimethylpyridine;
In
dichloromethane;
at 0 ℃;
With
sodium azide;
In
N,N-dimethyl-formamide;
at 20 ℃;
DOI:10.1016/S0040-4039(02)00681-0
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) NaH, 2.) (Bu)4NI / 1.) THF, 2.) THF
2: 1N aq. H2SO4 / acetone
3: H2 / Pd/C / tetrahydrofuran
4: dioxane
5: Ph3P, DEAD / tetrahydrofuran
6: KOH / ethanol
7: HN3, PH3P, DEAD / toluene
With
potassium hydroxide; tris-(2-chloro-ethyl)-amine; sulfuric acid; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; triphenylphosphine; diethylazodicarboxylate;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; ethanol; acetone; toluene;
