(R)-1-(4-bromophenyl)ethyl acetate

Base Information

• Chemical Name: (R)-1-(4-bromophenyl)ethyl acetate
• CAS No.: 103966-62-7
• Molecular Formula: C₁₀H₁₁BrO₂
• Molecular Weight: 243.1
• Mol file: 103966-62-7.mol

Synonyms:(R)-1-(4-bromophenyl)ethyl acetate

Chemical Property of (R)-1-(4-bromophenyl)ethyl acetate

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(4-bromophenyl)ethyl acetate

There total 28 articles about (R)-1-(4-bromophenyl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chlorophenyl acetate (876-27-7) + 1-(4-bromophenyl)ethanol (5391-88-8) → (S)-1-(4-bromophenyl)ethanol (5391-88-8,25675-29-0,76155-78-7,100760-04-1) + (R)-1-(4-bromophenyl)ethyl acetate (103966-62-7)

Guidance literature:

With (η5-indenyl)ruthenium(bis(triphenylphosphine))chloride; Pseudomonas cepocia lipase; triethylamine; at 60 ℃; for 43h; Enzymatic reaction;

DOI:10.1016/S0040-4039(99)01237-X

Reference yield: 98.0%

para-bromoacetophenone (99-90-1) + ethyl acetate (141-78-6) → (R)-1-(4-bromophenyl)ethyl acetate (103966-62-7)

Guidance literature:

With novozyme 435; dicarbonylhydro[2,5-di(trimethylsilyl)-3,4-butylene-1-hydroxy(η5-cyclopentadienyl)]iron; hydrogen; In toluene; at 90 ℃; under 750.075 Torr; enantioselective reaction; Schlenk technique; Enzymatic reaction;

DOI:10.1002/cssc.201700169

Reference yield: 97.0%

Isopropenyl acetate (108-22-5) + 1-(4-bromophenyl)ethanol (5391-88-8) → (R)-1-(4-bromophenyl)ethyl acetate (103966-62-7)

Guidance literature:

With dicarbonylchlorido(pentabenzylcyclopentadienyl)ruthenium; potassium tert-butylate; sodium carbonate; In tetrahydrofuran; toluene; at 23 ℃; for 3h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; dynamic kinetic resolution; Enzymatic reaction;

DOI:10.1002/ejoc.201001703

upstream raw materials:

1,2-bis-[1-(4-bromophenyl)ethylidene]hydrazine

acetic acid

2-(p-bromo-α-methylbenzyloxy)tetrahydropyran

acetic anhydride

Downstream raw materials:

1-(1-azidoethyl)-4-bromobenzene

(R)-1-(4-bromophenyl)ethanol

(S)-1-(4-bromophenyl)ethyl acetate

(S)-1-(4-bromophenyl)ethanol

Refernces

• 1、 El-Sepelgy, Osama,Alandini, Nurtalya,Rueping, Magnus. "Merging Iron Catalysis and Biocatalysis—Iron Carbonyl Complexes as Efficient Hydrogen Autotransfer Catalysts in Dynamic Kinetic Resolutions". . p. 13602 - 13605. Retrieved 2016.
• 2、 Raval, Hiten B.,Bedekar, Ashutosh V.. "One-pot kinetic resolution-Mitsunobu reaction to access optically pure compounds, using silver salts in the substitution protocol". . p. 21238 - 21243. Retrieved 2020/12/31.
• 3、 Toyao, Takashi,Nurnobi Rashed, Md.,Morita, Yoshitsugu,Kamachi, Takashi,Hakim Siddiki,Ali, Md. A.,Touchy,Kon, Kenichi,Maeno, Zen,Yoshizawa, Kazunari,Shimizu, Ken-ichi. "Esterification of Tertiary Amides by Alcohols Through C?N Bond Cleavage over CeO2". . p. 449 - 456. Retrieved 2018/09/11.