1H-Inden-1-amine,6-fluoro-2,3-dihydro-,(1R)-(9CI)

Base Information

• Chemical Name: 1H-Inden-1-amine,6-fluoro-2,3-dihydro-,(1R)-(9CI)
• CAS No.: 790208-54-7
• Molecular Formula: C₉H₁₀FN
• Molecular Weight: 151.184
• Mol file: 790208-54-7.mol

Synonyms:1H-Inden-1-amine,6-fluoro-2,3-dihydro-,(1R)-(9CI)

Chemical Property of 1H-Inden-1-amine,6-fluoro-2,3-dihydro-,(1R)-(9CI)

Chemical Property:

• Vapor Pressure: 0.202mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 209.531°C at 760 mmHg
• Flash Point: 89.93°C
• PSA: 26.02000
• Density: 1.16g/cm³
• LogP: 2.47200
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

(R)-6-Fluoro-indan-1-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Inden-1-amine,6-fluoro-2,3-dihydro-,(1R)-(9CI)

There total 4 articles about 1H-Inden-1-amine,6-fluoro-2,3-dihydro-,(1R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(1R)-1-azido-6-fluoro-2,3-dihydro-1H-indene → (1R)-6-fluoro-2,3-dihydro-1H-inden-1-amine (790208-54-7,1383854-81-6)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In ethanol; for 1h; under 2585.81 Torr; Inert atmosphere;

Reference yield:

6-fluoroindan-1-ylamine (148960-37-6,168902-77-0,148960-36-5,1383854-81-6) → (1R)-6-fluoro-2,3-dihydro-1H-inden-1-amine (790208-54-7,1383854-81-6) + C9H8FN

Guidance literature:

With borane-ammonia complex; monoamine oxidase variant D₉ from Aspergillus niger; In dimethyl sulfoxide; at 37 ℃; for 24h; pH=9; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.bmc.2017.07.023

Reference yield:

(1S)-6-fluoro-2,3-dihydro-1H-inden-1-ol → (1R)-6-fluoro-2,3-dihydro-1H-inden-1-amine (790208-54-7,1383854-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / toluene / 10 - 20 °C

2: hydrogen; 5%-palladium/activated carbon / ethanol / 1 h / 2585.81 Torr / Inert atmosphere

With diphenyl phosphoryl azide; 5%-palladium/activated carbon; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; toluene;

upstream raw materials:

6-fluoroindan-1-one

6-fluoroindan-1-ylamine

Refernces

• 1、 -. "INHIBITOR OF JAK1 AND JAK2". . . Retrieved 2014/01/08.