dihydroepiberberine

Base Information

• Chemical Name: dihydroepiberberine
• CAS No.: 51665-54-4
• Molecular Formula: C₂₀H₁₉NO₄
• Molecular Weight: 337.375
• Mol file: 51665-54-4.mol

Synonyms:dihydroepiberberine

Chemical Property of dihydroepiberberine

Chemical Property:

Purity/Quality:

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Technology Process of dihydroepiberberine

There total 1 articles about dihydroepiberberine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine (63375-81-5) → dihydroepiberberine (51665-54-4)

Guidance literature:

Multi-step reaction with 6 steps

1: CH₂Cl₂ / 24 h / 20 °C

2: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

3: Et₃N / CH₂Cl₂ / 0.33 h / 0 °C

4: SnCl₄ / CH₂Cl₂ / 1 h / 0 °C

5: 80 percent / Raney Ni / ethanol / 2 h / Heating

6: POCl₃; K₂CO₃ / acetonitrile / 0.67 h / 60 °C

With lithium aluminium tetrahydride; tin(IV) chloride; nickel; potassium carbonate; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 1: Condensation / 2: Reduction / 3: Acylation / 4: Cyclization / 5: desulfurization; debromination / 6: Bischler-Napieralski reaction;

DOI:10.1248/cpb.48.399

Reference yield:

dihydroepiberberine (51665-54-4) → Epiberberine (6873-09-2)

Guidance literature:

With iodine; potassium acetate; In ethanol; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201601245

upstream raw materials:

2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine

Downstream raw materials:

Epiberberine

Refernces