2,6-dimethyl-4-phenylmorpholine

Base Information

• Chemical Name: 2,6-dimethyl-4-phenylmorpholine
• CAS No.: 109605-09-6
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.273
• Mol file: 109605-09-6.mol

Synonyms:2,6-dimethyl-4-phenylmorpholine

Chemical Property of 2,6-dimethyl-4-phenylmorpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-dimethyl-4-phenylmorpholine

There total 7 articles about 2,6-dimethyl-4-phenylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-(2,6-dimethylmorpholino)benzaldehyde → 2,6-dimethyl-4-phenylmorpholine (109605-09-6)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; at 20 ℃; for 6h; Irradiation; Inert atmosphere; Green chemistry;

DOI:10.1039/d0gc01256d

Reference yield: 42.0%

2,6-dimethyl morpholine (141-91-3) + bromobenzene (108-86-1,52753-63-6) → 2,6-dimethyl-4-phenylmorpholine (109605-09-6)

Guidance literature:

With copper(l) iodide; potassium carbonate; L-proline; In dimethyl sulfoxide; at 90 ℃; for 24h;

DOI:10.1002/anie.201903019

Reference yield: 10.0%

4-phenyl-2,6-dimethyl-2-hydroxymorpholine → 2,6-dimethyl-4-phenylmorpholine (109605-09-6)

Guidance literature:

With aniline; methyloxirane;

upstream raw materials:

N-phenyl-bis-(2-hydroxypropyl)amine

1,2-propylene cyclic carbonate

aniline

2,6-dimethyl morpholine

Downstream raw materials:

2,6-dimethyl-4-[4-(4-nitro-phenylazo)-phenyl]-morpholine

Refernces

• 1、 Beller, Matthias,Junge, Kathrin,Leonard, David K.,Li, Wu,Rockstroh, Nils. "Aerobic iron-catalyzed site-selective C(sp3)–C(sp3) bond cleavage in N-heterocycles". . . Retrieved 2021/06/26.
• 2、 Li, Wu,Liu, Weiping,Leonard, David K.,Rabeah, Jabor,Junge, Kathrin,Brückner, Angelika,Beller, Matthias. "Practical Catalytic Cleavage of C(sp3)?C(sp3) Bonds in Amines". supporting information. p. 10693 - 10697. Retrieved 2019/07/09.