3-(4-BROMOPHENYL)-DL-BETA-ALANINOL

Base Information

• Chemical Name: 3-(4-BROMOPHENYL)-DL-BETA-ALANINOL
• CAS No.: 787615-14-9
• Molecular Formula: C9H12 Br N O
• Molecular Weight: 230.104
• Hs Code.: 2922199090
• Mol file: 787615-14-9.mol

Synonyms:3-Amino-3-(4-bromophenyl)propan-1-ol

Chemical Property of 3-(4-BROMOPHENYL)-DL-BETA-ALANINOL

Chemical Property:

• Vapor Pressure: 1.87E-05mmHg at 25°C
• Refractive Index: 1.593
• Boiling Point: 348.6°C at 760 mmHg
• Flash Point: 164.6°C
• PSA: 46.25000
• Density: 1.466g/cm³
• LogP: 2.53160

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-3-(4-bromophenyl)propan-1-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-BROMOPHENYL)-DL-BETA-ALANINOL

There total 4 articles about 3-(4-BROMOPHENYL)-DL-BETA-ALANINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-3-(4'-bromophenyl)propanoic acid (39773-47-2,295356-30-8) → 3-amino-3-(4-bromophenyl)propan-1-ol (787615-14-9,1213037-93-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 5.5h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2020.131064

Reference yield:

C11H11BrCl3NO → 3-amino-3-(4-bromophenyl)propan-1-ol (787615-14-9,1213037-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: cesium iodide; phthaloyl peroxide / acetonitrile / 8 h / Irradiation; Inert atmosphere

2: hydrogenchloride / methanol; water / 2 h

With hydrogenchloride; phthaloyl peroxide; cesium iodide; In methanol; water; acetonitrile;

DOI:10.1002/anie.202008806

Reference yield:

C11H9BrCl3NO → 3-amino-3-(4-bromophenyl)propan-1-ol (787615-14-9,1213037-93-4)

Guidance literature:

With hydrogenchloride; In methanol; water; for 2h;

DOI:10.1002/anie.202008806

upstream raw materials:

4-bromo-benzaldehyde

3-amino-3-(4'-bromophenyl)propanoic acid

Downstream raw materials:

4-(4-bromophenyl)-1,3-oxazinan-2-one

Refernces

• 1、 Fang, Yuanding,Fu, Kang,Shi, Lei,Zhao, Rong,Zhou, Jia. "Site-Specific C(sp3)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions". . p. 20682 - 20690. Retrieved 2020/09/07.