4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide

Base Information

• Chemical Name: 4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide
• CAS No.: 97308-41-3
• Molecular Formula: C₁₆H₁₄N₂O
• Molecular Weight: 250.3
• Mol file: 97308-41-3.mol

Synonyms:4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide

Chemical Property of 4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide

There total 5 articles about 4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

4,6-dimethyl-3-phenylethynyl-2-pyridinecarbonitrile (97308-40-2) → 4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide (97308-41-3)

Guidance literature:

With dihydrogen peroxide; sodium carbonate; In acetone; for 20h; Ambient temperature;

Reference yield:

5-amino-2,4-dimethylpyridine (1193-71-1) → 4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide (97308-41-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 56 percent / CuBr, 47percent HBr, NaNO₂ / H₂O / 1.) 10 deg C, 2.) room temp., 30 min, 3.) 80 deg C, 20 min

2: 59 percent / 35percent H₂O₂ / acetic acid / 20 h / 110 °C

3: 64 percent / Et₃N / acetonitrile / 20 h / Heating

4: 60 percent / CuI / Pd(PPh₃)2Cl₂ / triethylamine / 24 h / 100 °C

5: 69 percent / 3N Na₂CO₃, 15percent H₂O₂ / acetone / 20 h / Ambient temperature

With copper(l) iodide; hydrogen bromide; dihydrogen peroxide; sodium carbonate; triethylamine; copper(I) bromide; sodium nitrite; bis-triphenylphosphine-palladium(II) chloride; In water; acetic acid; triethylamine; acetone; acetonitrile;

Reference yield:

5-bromo-2,4-dimethyl-pyridine (27063-92-9) → 4,6-dimethyl-3-phenylethynyl-2-pyridinecarboxamide (97308-41-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 59 percent / 35percent H₂O₂ / acetic acid / 20 h / 110 °C

2: 64 percent / Et₃N / acetonitrile / 20 h / Heating

3: 60 percent / CuI / Pd(PPh₃)2Cl₂ / triethylamine / 24 h / 100 °C

4: 69 percent / 3N Na₂CO₃, 15percent H₂O₂ / acetone / 20 h / Ambient temperature

With copper(l) iodide; dihydrogen peroxide; sodium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetic acid; triethylamine; acetone; acetonitrile;

upstream raw materials:

4,6-dimethyl-3-phenylethynyl-2-pyridinecarbonitrile

5-amino-2,4-dimethylpyridine

5-bromo-2,4-dimethyl-pyridine

3-bromo-4,6-dimethylpyridine 1-oxide

Downstream raw materials:

2,4-dimethyl-6-phenyl-1,7-naphthyridin-8(7H)-one

Refernces