Technology Process of Boc-Leu-Glu(OBut)-Gly-Pro-Pro-Gln-Lys-N2H3
There total 16 articles about Boc-Leu-Glu(OBut)-Gly-Pro-Pro-Gln-Lys-N2H3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
In
methanol;
for 72h;
Ambient temperature;
DOI:10.1246/bcsj.53.192
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 82.2 percent / 1.) TEA / tetrahydrofuran / 96 h / Ambient temperature
2: H2 / 5percent palladium-charcoal / methanol / 2.5 h / 35 °C
3: 1.) TEA / CHCl3 / 72 h / Ambient temperature
4: 1.) N-methylmorpholine, DCC, 2.) 1-hydroxybenzotriazole (HOBt), DCC / tetrahydrofuran / 96 h / 0 - 20 °C
5: 67 percent / NH2NH2*H2O / methanol / 72 h / Ambient temperature
With
4-methyl-morpholine; TEA; hydrogen; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; chloroform;
DOI:10.1246/bcsj.53.192
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dimethylformamide; CH2Cl2 / 1 h / Ambient temperature
2: 1 M NaOH / dioxane / 2 h / Ambient temperature
3: 1.) N-methylmorpholine, DCC, 2.) 1-hydroxybenzotriazole (HOBt), DCC / tetrahydrofuran / 96 h / 0 - 20 °C
4: 67 percent / NH2NH2*H2O / methanol / 72 h / Ambient temperature
With
4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; hydrazine hydrate; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.53.192
