1-(4-SULFONO MORPHOLINE)ACETONITRILE

Base Information

• Chemical Name: 1-(4-SULFONO MORPHOLINE)ACETONITRILE
• CAS No.: 79207-43-5
• Molecular Formula: C₆H₁₀N₂O₂S
• Molecular Weight: 174.224
• Mol file: 79207-43-5.mol

Synonyms:1-(4-SULFONO MORPHOLINE)ACETONITRILE;1-DIOXIDE-4-THIOMORPHOLINEACETONITRILE;4-THIOMORPHOLINE ACETONITRILE, 1,1-DIOXIDE

Chemical Property of 1-(4-SULFONO MORPHOLINE)ACETONITRILE

Chemical Property:

• Vapor Pressure: 1.2E-06mmHg at 25°C
• Refractive Index: 1.51
• Boiling Point: 401.3°C at 760 mmHg
• Flash Point: 196.5°C
• PSA: 69.55000
• Density: 1.29g/cm³
• LogP: 0.25908

Purity/Quality:

95%-98% ^*data from raw suppliers

2-(1,1-dioxo-1lambda6-thiomorpholin-4-yl)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-SULFONO MORPHOLINE)ACETONITRILE

There total 2 articles about 1-(4-SULFONO MORPHOLINE)ACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

thiomorpholine 1,1-dioxide (39093-93-1) + cyanomethyl bromide (590-17-0) → 4-Cyanomethyl-thiomorpholin-S-dioxid (79207-43-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃; for 16h;

Reference yield: 40.0%

thiomorpholine 1,1-dioxide (39093-93-1) + chloroacetonitrile (107-14-2) → 4-Cyanomethyl-thiomorpholin-S-dioxid (79207-43-5)

Guidance literature:

With sodium carbonate; for 12h; Heating;

DOI:10.1007/BF00899678

Reference yield: 98.0%

4-Cyanomethyl-thiomorpholin-S-dioxid (79207-43-5) → 2-(1,1-Dioxo-thiomorpholin-4-yl)-ethylamine (89937-52-0)

Guidance literature:

With ammonia; hydrogen; Raney nickel; In methanol; at 70 ℃; under 52505.3 Torr;

upstream raw materials:

thiomorpholine 1,1-dioxide

chloroacetonitrile

cyanomethyl bromide

Downstream raw materials:

2-(1,1-Dioxo-thiomorpholin-4-yl)-ethylamine

N-[2-(1,1-Dioxidothiomorpholin-4-yl)ethyl]-5-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridine-2-amine

Refernces

• 1、 Asinger, Friedrich,Kaussen, Manfred,Gold-Martin, Irmgard,Saus, Alfons. "Concerning the Reactivity of Unsubstituted and Alkyl Substituted Thiomorpholines, 5. On the Joint Action of Elementary Sulfur and Gaseous Ammonia on Ketones, 95". . p. 643 - 657. Retrieved 2007/10/02.