tert-Butyl 2-cyclopentylidenehydrazinecarboxylate

Base Information

• Chemical Name: tert-Butyl 2-cyclopentylidenehydrazinecarboxylate
• CAS No.: 79201-39-1
• Molecular Formula: C10H18 N2 O2
• Molecular Weight: 198.26212
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID60398874
• Mol file: 79201-39-1.mol

Synonyms:79201-39-1;tert-Butyl 2-cyclopentylidenehydrazinecarboxylate;tert-butyl N-(cyclopentylideneamino)carbamate;tert-Butyl cyclopentylidenecarbazate;N'-cyclopentylidene(tert-butoxy)carbohydrazide;SCHEMBL573354;DTXSID60398874;JIWAYUZEWSSBRC-UHFFFAOYSA-N;HMS1784N17;AB6630;MFCD00471042;AKOS006241109;BB 0258805;FT-0656442;EN300-66232;tert-butyl 2-cyclopentylidenehyrazinecarboxylate;tert-Butyl2-cyclopentylidenehydrazinecarboxylate;A839615;tert-Butyl 2-cyclopentylidenehydrazine-1-carboxylate;N'-[(1Z)-cyclopentylidene](tert-butoxy)carbohydrazide;Z49621231;F9995-1168;N'-[(1Z)-Cyclopentylidene]-(tert-butoxy)carbohydrazide;1-cyclopentylidenehydrazine-2-carboxylic acid tert-butyl ester;N'-cyclopentylidene-hydrazinecarboxylic acid tert-butyl ester;Hydrazinecarboxylicacid,2-cyclopentylidene-,1,1-dimethylethyl ester;HYDRAZINECARBOXYLICACID, 2-CYCLOPENTYLIDENE-, 1,1-DIMETHYLETHYL ESTER;(tert-butoxyamino)-cyclopentylidene-(hydrazinecarbonyl)ammonium

Chemical Property of tert-Butyl 2-cyclopentylidenehydrazinecarboxylate

Chemical Property:

• Refractive Index: 1.513
• PSA: 54.18000
• Density: 1.09g/cm³
• LogP: 2.64550
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 198.136827821
• Heavy Atom Count: 14
• Complexity: 233

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl2-Cyclopentylidenehydrazinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NN=C1CCCC1

Technology Process of tert-Butyl 2-cyclopentylidenehydrazinecarboxylate

There total 2 articles about tert-Butyl 2-cyclopentylidenehydrazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

t-butoxycarbonylhydrazine (870-46-2) + cyclopentanone (120-92-3) → tert-butyl 2-cyclopentylidenehydrazine carboxylate (79201-39-1)

Guidance literature:

In methanol; at 20 ℃; for 2h;

DOI:10.1021/jm030276s

Reference yield:

→ tert-butyl 2-cyclopentylidenehydrazine carboxylate (79201-39-1)

Guidance literature:

Reference yield: 100.0%

tert-butyl 2-cyclopentylidenehydrazine carboxylate (79201-39-1) → cyclopentylhydrazine hydrochloride (24214-72-0,645372-27-6)

Guidance literature:

tert-butyl 2-cyclopentylidenehydrazine carboxylate; With sodium cyanoborohydride; In tetrahydrofuran; methanol; for 0.166667h; Heating / reflux;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 20 ℃; for 4.5h; Heating / reflux;

upstream raw materials:

t-butoxycarbonylhydrazine

cyclopentanone

Downstream raw materials:

tert-butyl 2-cyclopentylhydrazinecarboxylate

cyclopentylhydrazine hydrochloride

cyclopentylhydrazine

(1-cyclopentyl-5-(4-methylthiophenyl)pyrazol-3-yl)methanol

Refernces

• 1、 Maitra, Rangan,Narayanan, Sanju,Rajagopal, Sudarshan,Runyon, Scott P.,Vasukuttan, Vineetha. "Identification of potent pyrazole based APELIN receptor (APJ) agonists". . . Retrieved 2020/01/22.
• 2、 -. "PROTEIN KINASE INHIBITORS". Paragraph 0226. . Retrieved 2015/07/15.