C₂₄H₂₆Cl₃NO₆S

Base Information

• Chemical Name: C₂₄H₂₆Cl₃NO₆S
• CAS No.: 1086092-45-6
• Molecular Formula: C₂₄H₂₆Cl₃NO₆S
• Molecular Weight: 562.899
• Mol file: 1086092-45-6.mol

Synonyms:C₂₄H₂₆Cl₃NO₆S

Chemical Property of C₂₄H₂₆Cl₃NO₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₆Cl₃NO₆S

There total 1 articles about C₂₄H₂₆Cl₃NO₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

C18H22Cl3NO7 + para-thiocresol (106-45-6) → C24H26Cl3NO6S (1086092-45-6)

Guidance literature:

With boron trifluoride diethyl etherate; In 1,2-dichloro-ethane; at 40 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmc.2008.08.053

Reference yield: 90.0%

C24H26Cl3NO6S (1086092-45-6) → C15H19NO4S (1086092-62-7)

Guidance literature:

With methylamine; In ethanol; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmc.2008.08.053

Reference yield:

C24H26Cl3NO6S (1086092-45-6) → gentamicin B (74464-85-0,36889-15-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: methylamine / 24 h

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 3 h / 0 - 20 °C / Inert atmosphere

3.1: N-iodo-succinimide / dichloromethane / 0.5 h / 20 °C / Molecular sieve

3.2: -78 - 0 °C

4.1: sodium hydroxide / ethanol / 10 h / 90 °C

5.1: sodium hydroxide; trimethylphosphane / tetrahydrofuran / 2 h / 50 °C

5.2: 24 h / 20 °C

With N-iodo-succinimide; sodium hydride; methylamine; sodium hydroxide; trimethylphosphane; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jacs.7b09890

upstream raw materials:

para-thiocresol

Downstream raw materials:

C₁₅H₁₉NO₄S

gentamicin B

Refernces

• 1、 Chen, Lilach,Hainrichson, Mariana,Bourdetsky, Dmitry,Mor, Amram,Yaron, Sima,Baasov, Timor. "Structure-toxicity relationship of aminoglycosides: Correlation of 2′-amine basicity with acute toxicity in pseudo-disaccharide scaffolds". experimental part. p. 8940 - 8951. Retrieved 2009/04/03.