4-Carbamyl-1-piperazinecarboxylic acid benzyl ester

Base Information

• Chemical Name: 4-Carbamyl-1-piperazinecarboxylic acid benzyl ester
• CAS No.: 588-88-5
• Molecular Formula: C13H17 N3 O3
• Molecular Weight: 263.296
• Mol file: 588-88-5.mol

Synonyms:1-Piperazinecarboxylicacid, 4-carbamoyl-, benzyl ester (6CI,8CI); Benzyl alcohol, 4-carbamoyl-,1-piperazinecarboxylate; 1-Carbamyl-4-carbobenzoxypiperazine; Benzyl4-carbamoyl-1-piperazinecarboxylate; Benzyl 4-carbamyl-1-piperazinecarboxylate;Hibital

Chemical Property of 4-Carbamyl-1-piperazinecarboxylic acid benzyl ester

Chemical Property:

• Vapor Pressure: 5.28E-09mmHg at 25°C
• Boiling Point: 470°C at 760 mmHg
• Flash Point: 238°C
• PSA: 75.87000
• Density: 1.25g/cm³
• LogP: 1.59560

Purity/Quality:

4-Carbamoylpiperazine-1-carboxylic acid benzyl ester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Carbamyl-1-piperazinecarboxylic acid benzyl ester

There total 4 articles about 4-Carbamyl-1-piperazinecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylsilyl isocyanate (1118-02-1) + phenylmethyl 1-piperazinecarboxylate (31166-44-6) → benzyl 4-carbamoylpiperazine-1-carboxylate (588-88-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

phenylmethyl 1-piperazinecarboxylate (31166-44-6) + urea (57-13-6) → benzyl 4-carbamoylpiperazine-1-carboxylate (588-88-5)

Guidance literature:

With Iron(III) nitrate nonahydrate; In toluene; for 16h; Reflux;

DOI:10.1002/anie.201904662

Reference yield:

nitrourea (556-89-8) + phenylmethyl 1-piperazinecarboxylate (31166-44-6) → benzyl 4-carbamoylpiperazine-1-carboxylate (588-88-5)

Guidance literature:

With water;

DOI:10.1021/jo50013a007

upstream raw materials:

nitrourea

phenylmethyl 1-piperazinecarboxylate

benzyl piperazine-1-carboxylate hydrochloride

trimethylsilyl isocyanate

Downstream raw materials:

1-piperazine carboxamide

Refernces

• 1、 -. "Beta lactam compounds and their use as inhibitors of tryptase". Page column 154. . Retrieved 2010/11/29.