Technology Process of 2-[3,5-di-iso-propyl-6-(2,2,2-trifluoroethoxy)benzene]-4-formylpyridine
There total 5 articles about 2-[3,5-di-iso-propyl-6-(2,2,2-trifluoroethoxy)benzene]-4-formylpyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
ethanol; toluene;
Heating;
DOI:10.1021/jm020401k
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 99 percent / N-iodosuccinimide; p-toluenesulfonic acid / CH2Cl2 / 20 °C
2.1: 91 percent / Cs2CO3 / dimethylformamide / 16 h / 50 °C
3.1: n-BuLi; TMEDA / diethyl ether; hexane / 0.25 h / -78 °C
3.2: diethyl ether / -78 - 0 °C
4.1: aq. HCl / diethyl ether / 1 h / 23 °C
5.1: 72 percent / Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / Heating
With
hydrogenchloride; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; caesium carbonate; toluene-4-sulfonic acid;
In
diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
5.1: Suzuki coupling;
DOI:10.1021/jm020401k
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 91 percent / Cs2CO3 / dimethylformamide / 16 h / 50 °C
2.1: n-BuLi; TMEDA / diethyl ether; hexane / 0.25 h / -78 °C
2.2: diethyl ether / -78 - 0 °C
3.1: aq. HCl / diethyl ether / 1 h / 23 °C
4.1: 72 percent / Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / Heating
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium carbonate; caesium carbonate;
In
diethyl ether; ethanol; hexane; N,N-dimethyl-formamide; toluene;
4.1: Suzuki coupling;
DOI:10.1021/jm020401k
