Technology Process of 2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole
There total 4 articles about 2-(1-methoxy-1-phenylmethyl)-4,5-dimethylthiazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(1-hydroxy-1-phenylmethyl)-4,5-dimethylthiazole;
With
sodium hydride;
In
tetrahydrofuran;
at -50 ℃;
for 0.5h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran;
at -50 - 20 ℃;
for 2.5h;
Inert atmosphere;
DOI:10.1002/anie.201204524
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C
1.2: 41 percent / tetrahydrofuran / 1.25 h / -78 - 20 °C
2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
2.2: 83 percent / tetrahydrofuran / 3.5 h / 20 °C
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran;
1.1: Metallation / 1.2: Addition / 2.1: Metallation / 2.2: Methylation;
DOI:10.1021/ja9633528
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C
1.2: 41 percent / tetrahydrofuran / 1.25 h / -78 - 20 °C
2.1: NaH / tetrahydrofuran / 0.5 h / 0 °C
2.2: 83 percent / tetrahydrofuran / 3.5 h / 20 °C
With
n-butyllithium; sodium hydride;
In
tetrahydrofuran;
1.1: Metallation / 1.2: Addition / 2.1: Metallation / 2.2: Methylation;
DOI:10.1021/ja9633528
