(Z)-2'-Acetamido-α-bromochalcone

Base Information

• Chemical Name: (Z)-2'-Acetamido-α-bromochalcone
• CAS No.: 124857-06-3
• Molecular Formula: C₁₇H₁₄BrNO₂
• Molecular Weight: 344.208
• Mol file: 124857-06-3.mol

Synonyms:(Z)-2'-Acetamido-α-bromochalcone

Chemical Property of (Z)-2'-Acetamido-α-bromochalcone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2'-Acetamido-α-bromochalcone

There total 9 articles about (Z)-2'-Acetamido-α-bromochalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

2'-Acetamidochalcone Dibromide (124856-93-5) → (E)-2'-Acetamido-α-bromochalcone (124857-05-2) + (Z)-2'-Acetamido-α-bromochalcone (124857-06-3)

Guidance literature:

With potassium acetate; In acetone;

DOI:10.1021/jo00293a017

Reference yield: 15.0%

1-(2-Acetamidophenyl)-2-bromo-3-methoxy-3-phenyl-1-propanone (124856-96-8) → (Z)-2'-Acetamido-α-bromochalcone (124857-06-3)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; for 1h;

DOI:10.1021/jo00293a017

Reference yield:

2-aminochalcone (78396-00-6) → (Z)-2'-Acetamido-α-bromochalcone (124857-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / pyridine

2: 60 percent / NBBS / methanol / 3 h

3: 15 percent / aq. KOH / tetrahydrofuran / 1 h

With pyridine; potassium hydroxide; N-butylbenzenesulfonamide; In tetrahydrofuran; methanol;

DOI:10.1021/jo00293a017

upstream raw materials:

2'-Aminochalcone Dibromide

2'-Acetamidochalcone Dibromide

1-(2-Acetamidophenyl)-2-bromo-3-methoxy-3-phenyl-1-propanone

acetic anhydride

Downstream raw materials:

2-phenyl-1H-quinolin-4-one

Refernces