N-(5-FLUORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE

Base Information

• Chemical Name: N-(5-FLUORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE
• CAS No.: 784155-54-0
• Molecular Formula: C₁₀H₁₃FN₂O
• Molecular Weight: 196.224
• Hs Code.: 2933399090
• Mol file: 784155-54-0.mol

Synonyms:N-(5-Fluoropyridin-2-yl)-2,2-dimethylpropanamide;N-(5-Fluoropyridin-2-yl)-2,2-dimethylpropionamide; N-(5-fluoropyridin-2-yl)-2,2-dimethylpropionamide

Chemical Property of N-(5-FLUORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 333.316°C at 760 mmHg
• Flash Point: 155.384°C
• PSA: 41.99000
• Density: 1.158g/cm³
• LogP: 2.27830

Purity/Quality:

98%Min ^*data from raw suppliers

N-(5-Fluoro-pyridin-2-yl)-2,2-dimethyl-propionamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-FLUORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE

There total 3 articles about N-(5-FLUORO-PYRIDIN-2-YL)-2,2-DIMETHYL-PROPIONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

pivaloyl chloride (3282-30-2) + 2-amino-5-fluoropyridine (21717-96-4) → N-(5-fluoropyridin-2-yl)-2,2-dimethylpropanamide (784155-54-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol401540k

Reference yield:

2-chloro-5-fluoropyridine (31301-51-6) → N-(5-fluoropyridin-2-yl)-2,2-dimethylpropanamide (784155-54-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; palladium diacetate / 1,4-dioxane / 50 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 20 °C

3: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With palladium diacetate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;

Reference yield:

N-(diphenylmethylidene)-5-fluoropyridin-2-amine → N-(5-fluoropyridin-2-yl)-2,2-dimethylpropanamide (784155-54-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

pivaloyl chloride

2-amino-5-fluoropyridine

2-chloro-5-fluoropyridine

Downstream raw materials:

2-amino-5-fluoropyridine-3-carbaldehyde

2-(6-fluoro-2-trifluoromethyl-[1,8]-naphthyridine-3-carbonyl)cyclohexane-1,3-dione

N-(5-fluoro-3-formylpyridin-2-yl)-2,2-dimethylpropanamide

N-(5-fluoro-3-iodo-pyridin-2-yl)-2,2-dimethyl-propionamide

Refernces

• 1、 Zhou, Jun,Li, Bo,Hu, Fang,Shi, Bing-Feng. "Rhodium(III)-catalyzed oxidative olefination of pyridines and quinolines: Multigram-scale synthesis of naphthyridinones". supporting information. p. 3460 - 3463. Retrieved 2013/07/26.
• 2、 -. "HERBICIDAL COUMPOUNDS". Page/Page column 104. . Retrieved 2009/10/22.