5-chloro-2-fluoro-4'-methoxylbenzophenone

Base Information

• Chemical Name: 5-chloro-2-fluoro-4'-methoxylbenzophenone
• CAS No.: 133436-34-7
• Molecular Formula: C₁₄H₁₀ClFO₂
• Molecular Weight: 264.684
• Mol file: 133436-34-7.mol

Synonyms:5-chloro-2-fluoro-4'-methoxylbenzophenone

Chemical Property of 5-chloro-2-fluoro-4'-methoxylbenzophenone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-chloro-2-fluoro-4'-methoxylbenzophenone

There total 2 articles about 5-chloro-2-fluoro-4'-methoxylbenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

5-chloro-2-fluoro-benzoyl chloride (394-29-6) + methoxybenzene (100-66-3) → 5-chloro-2-fluoro-4'-methoxylbenzophenone (133436-34-7)

Guidance literature:

With aluminum (III) chloride; at 0 - 50 ℃; for 3h;

DOI:10.1039/c3ta12026k

Reference yield:

5-chloro-2-fluorobenzoic acid (394-30-9) → 5-chloro-2-fluoro-4'-methoxylbenzophenone (133436-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 10 h / 85 °C

2: aluminum (III) chloride / 3 h / 0 - 50 °C

With aluminum (III) chloride; thionyl chloride;

DOI:10.1039/c3ta12026k

Reference yield: 46.0%

5-chloro-2-fluoro-4'-methoxylbenzophenone (133436-34-7) → bis[4-fluoro-3-(4'-methoxylbenzoyl)]biphenyl (1455108-87-8)

Guidance literature:

With bis(triphenylphosphine)nickel(II) chloride; tetraethylammonium iodide; zinc; In tetrahydrofuran; at 50 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c3ta12026k

upstream raw materials:

5-chloro-2-fluorobenzoic acid

5-chloro-2-fluoro-benzoyl chloride

methoxybenzene

Downstream raw materials:

bis[4-fluoro-3-(4'-methoxylbenzoyl)]biphenyl

Refernces