Technology Process of tris(3,4-dimethoxyphenyl)bismuthane
There total 3 articles about tris(3,4-dimethoxyphenyl)bismuthane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-Bromoveratrole;
With
n-butyllithium;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
bismuth(III) chloride;
at -78 - 20 ℃;
for 14.5h;
DOI:10.1002/ejoc.201600154
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran; hexane;
soln. of BuLi in hexane was added dropwise to soln. of aryl bromide in THF at -78°C over 15 min; mixt. was stirred for 15 min; BiCl3 was added over 30 min; mixt. was stirred at -78°C for 1 h; warmed to room temp.; stirred overnight; quenched with aq. NH4Cl; extd. (EtOAc or CH2Cl2); org. layer washed (brine); dried (Na2SO4 or MgSO4); solvent removed (vac.); chromd. (silica gel, pentane/Et2O, 1/1); elem. anal.;
DOI:10.1016/j.jorganchem.2006.01.022
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide / tetrachloromethane / 4 h / 30 °C
2.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C
2.2: 14.5 h / -78 - 20 °C
With
N-Bromosuccinimide; n-butyllithium;
In
tetrahydrofuran; tetrachloromethane;
DOI:10.1002/ejoc.201600154
