14-O-phosphonooxymethyltriptolide dibenzyl ester

Base Information

• Chemical Name: 14-O-phosphonooxymethyltriptolide dibenzyl ester
• CAS No.: 1254702-92-5
• Molecular Formula: C₃₅H₃₉O₁₀P
• Molecular Weight: 650.662
• Mol file: 1254702-92-5.mol

Synonyms:14-O-phosphonooxymethyltriptolide dibenzyl ester

Chemical Property of 14-O-phosphonooxymethyltriptolide dibenzyl ester

Chemical Property:

• Melting Point: 62-66°C

Purity/Quality:

>95% ^*data from raw suppliers

TriptolideO-MethylPhosphateDibenzylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Triptolide O-Methyl Phosphate Dibenzyl Ester is a derivative of Triptolide (T815600), a prodrug used for treatment of cancer.

Technology Process of 14-O-phosphonooxymethyltriptolide dibenzyl ester

There total 2 articles about 14-O-phosphonooxymethyltriptolide dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

triptolide methylthiomethyl ether (847440-49-7) + phosphoric acid dibenzyl ester (1623-08-1) → 14-O-phosphonooxymethyltriptolide dibenzyl ester (1254702-92-5)

Guidance literature:

With N-iodo-succinimide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 5h; Molecular sieve; Inert atmosphere;

Reference yield:

triptolide (38748-32-2,73414-46-7,73543-06-3,144539-79-7) → 14-O-phosphonooxymethyltriptolide dibenzyl ester (1254702-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dibenzoyl peroxide / acetonitrile / 2.33 h / 0 - 20 °C

2: N-iodo-succinimide / tetrahydrofuran; dichloromethane / 5 h / 20 °C / Inert atmosphere; Molecular sieve

With N-iodo-succinimide; dibenzoyl peroxide; In tetrahydrofuran; dichloromethane; acetonitrile;

upstream raw materials:

triptolide methylthiomethyl ether

phosphoric acid dibenzyl ester

triptolide

Refernces

• 1、 -. "TRIPTOLIDE PRODRUGS". Page/Page column 23-24. . Retrieved 2010/11/18.