2-(4-broMophenyl)Malonic acid

Base Information

• Chemical Name: 2-(4-broMophenyl)Malonic acid
• CAS No.: 773873-10-2
• Molecular Formula: C₉H₇BrO₄
• Molecular Weight: 259.056
• Mol file: 773873-10-2.mol

Synonyms:2-(4-bromophenyl)propanedioic acid

Chemical Property of 2-(4-broMophenyl)Malonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4-broMophenyl)Malonic acid

There total 4 articles about 2-(4-broMophenyl)Malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-(4-bromophenyl)malonic acid diethyl ester (93139-85-6) → 2-(4-bromophenyl)propanedioic acid (773873-10-2)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.organomet.7b00206

Reference yield:

2-(4-bromophenyl)-acetic acid (1878-68-8) → 2-(4-bromophenyl)propanedioic acid (773873-10-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / methanol / 12 h / Inert atmosphere; Reflux

2: sodium hydride / mineral oil; tetrahydrofuran / 53 h / 20 °C / Inert atmosphere; Reflux

3: sodium hydroxide / water; diethyl ether / Inert atmosphere

With sulfuric acid; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; water; mineral oil;

DOI:10.1002/chem.201800641

Reference yield:

2-(4-bromophenyl)-malonic acid dimethyl ester (149506-35-4) → 2-(4-bromophenyl)propanedioic acid (773873-10-2)

Guidance literature:

With sodium hydroxide; In diethyl ether; water; Inert atmosphere;

DOI:10.1002/chem.201800641

upstream raw materials:

2-(4-bromophenyl)malonic acid diethyl ester

2-(4-bromophenyl)-acetic acid

2-(4-bromophenyl)-malonic acid dimethyl ester

(4-bromo-phenyl)-acetic acid methyl ester

Downstream raw materials:

(4-bromo-phenyl)-malonyl dichloride

Refernces

• 1、 Carter, Ashley,Mason, Alexander,Baker, Michael A.,Bettler, Donald G.,Changas, Angelo,McMillen, Colin D.,Tapu, Daniela. "Janus-Type Bis(maloNHC) and Its Zwitterionic Gold and Silver Metal Complexes". . p. 1867 - 1872. Retrieved 2017/05/15.