(2S)-(+)-2-(3-Methoxyphenyl)glycin

Base Information

• Chemical Name: (2S)-(+)-2-(3-Methoxyphenyl)glycin
• CAS No.: 108647-55-8
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• Mol file: 108647-55-8.mol

Synonyms:(2S)-(+)-2-(3-Methoxyphenyl)glycin

Chemical Property of (2S)-(+)-2-(3-Methoxyphenyl)glycin

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

(S)-2-Amino-2-(3-methoxyphenyl)acetic acid 95+% ee ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-(+)-2-(3-Methoxyphenyl)glycin

There total 5 articles about (2S)-(+)-2-(3-Methoxyphenyl)glycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(2S)-(+)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-methoxyphenyl)essigsaeure (108594-41-8) → (2S)-(+)-2-(3-Methoxyphenyl)glycin (108647-55-8)

Guidance literature:

With hydrogenchloride; sodium periodate; In water; for 15h; Ambient temperature;

Reference yield: 46.0%

2-amino-2-(3-methoxyphenyl)acetonitrile (379232-33-4) → (2S)-(+)-2-(3-Methoxyphenyl)glycin (108647-55-8) + L-(+)-3-methoxyphenylglycine amide + D-(-)-3-methoxyphenylglycine amide

Guidance literature:

With Rhodococcus sp. AJ₂₇₀; In phosphate buffer; at 30 ℃; for 1.5h; pH=7.62;

DOI:10.1016/S0040-4039(01)01439-3

Reference yield:

3-methoxy-benzaldehyde (591-31-1) → (2S)-(+)-2-(3-Methoxyphenyl)glycin (108647-55-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄Cl

2: 46 percent / Rhodococcus sp. AJ₂₇₀ / aq. phosphate buffer / 1.5 h / 30 °C / pH 7.62

With Rhodococcus sp. AJ₂₇₀; ammonium chloride; In phosphate buffer;

DOI:10.1016/S0040-4039(01)01439-3

upstream raw materials:

(2S)-(+)-2-<(1S,2S)-(2-Hydroxy-1-hydroxymethyl-2-phenylethyl)amino>-2-(3-methoxyphenyl)essigsaeure

2-amino-2-(3-methoxyphenyl)acetonitrile

3-methoxy-benzaldehyde

Downstream raw materials:

(S)-tert-Butoxycarbonylamino-(4-formyl-3-hydroxy-phenyl)-acetic acid

(2S)-(+)-N-tert-Butoxycarbonyl-2-(3-hydroxy-4-hydroxymethylphenyl)glycin

(2S)-(+)-N-tert-Butoxycarbonyl-2-(3-hdroxyphenyl)glycin

L-(+)-Forphenicin

Refernces

• 1、 Wang, Mei-Xiang,Lin, Shuang-Jun. "Highly efficient and enantioselective synthesis of L-arylglycines and D-arylglycine amides from biotransformations of nitriles". . p. 6925 - 6927. Retrieved 2007/10/03.