1H-Imidazole-4-carboxylicacid,5-methyl-,methylester(9CI)

Base Information

• Chemical Name: 1H-Imidazole-4-carboxylicacid,5-methyl-,methylester(9CI)
• CAS No.: 78892-68-9
• Molecular Formula: C6H8 N2 O2
• Molecular Weight: 140.14
• Hs Code.: 2933290090
• Mol file: 78892-68-9.mol

Synonyms:1H-Imidazole-4-carboxylicacid, 5-methyl-, methyl ester (9CI); 5-Methyl-3H-imidazole-4-carboxylic acid methylester; Methyl 5-methyl-4-imidazolecarboxylate

Chemical Property of 1H-Imidazole-4-carboxylicacid,5-methyl-,methylester(9CI)

Chemical Property:

• PSA: 54.98000
• LogP: 0.50470

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 4-methyl-1H-imidazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Imidazole-4-carboxylicacid,5-methyl-,methylester(9CI)

There total 2 articles about 1H-Imidazole-4-carboxylicacid,5-methyl-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methanol (67-56-1) + 4(5)-methyl-5(4)-hydroxymethylimidazole (29636-87-1) → 5-methyl-4-imidazole carboxylic acid methyl ester (78892-68-9)

Guidance literature:

With manganese(IV) oxide; sodium cyanide; at 20 ℃; for 20h;

DOI:10.1016/S0968-0896(00)00152-8

Reference yield: 52.0%

acetoacetic acid methyl ester (105-45-3) → 5-methyl-4-imidazole carboxylic acid methyl ester (78892-68-9)

Guidance literature:

With hydrogenchloride; ammonium hydroxide; sodium nitrite; paraformaldehyde; In water; acetic acid;

Reference yield:

2-methylphenyl bromide (95-46-5) + 5-methyl-4-imidazole carboxylic acid methyl ester (78892-68-9) → 5-methyl-4-(2'-methylbenzoyl)imidazole

Guidance literature:

With sulfuric acid; magnesium; In tetrahydrofuran; ethanol; water;

upstream raw materials:

methanol

4⁽⁵⁾-methyl-5⁽⁴⁾-hydroxymethylimidazole

acetoacetic acid methyl ester

Downstream raw materials:

5-methyl-1H-imidazole-4-carboxylic acid hydrazide

(isopropylidene)-5-methyl-imidazole-4-carbohydrazide

4-[α,α-bis(2-methylphenyl)hydroxymethyl]-5-methylimidazole

Refernces

• 1、 -. "Process for preparing 5-methyl-4-imidazolecarboxylic acid esters". . . Retrieved 2008/06/13.