Technology Process of 6-chloro-9-<(2,2-dimethyl-1,3-dioxan-5-yl)methoxy>-2-formamidopurine
There total 1 articles about 6-chloro-9-<(2,2-dimethyl-1,3-dioxan-5-yl)methoxy>-2-formamidopurine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 86 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 16 h / Ambient temperature
2: 79 percent / methylhydrazine / CH2Cl2 / 1 h / 20 °C
3: 77 percent / diisopropylethylamine / bis-(2-methoxy-ethyl) ether / 2.5 h / 100 °C
4: 81 percent / various solvent(s) / 2 h / 120 °C
With
N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; diethylene glycol dimethyl ether;
DOI:10.1021/jm00163a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 43 percent / 1.) ammonium formate, 2.) hydrazine hydrate / 10percent Pd/charcoal / methanol / 1.) reflux, 4 h, 2.) reflux, 45 min
2: 87 percent / 80percent acetic acid / 3 h / Ambient temperature
3: 65 percent / 4-(dimethylamino)pyridine / dimethylformamide / Ambient temperature
With
dmap; ammonium formate; hydrazine hydrate; acetic acid;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 63 percent / NH3 / methanol / 7.5 h / 110 °C / autoclave
2: 78 percent / 80percent acetic acid / 4 h / Ambient temperature
3: 45 percent / 1.) 80percent aq formic acid, 2.) aq NH3 / 1.) 100 deg C, 2 h, 2.) RT, 0.5 h
With
ammonium hydroxide; formic acid; ammonia; acetic acid;
In
methanol;
DOI:10.1021/jm00163a031