BENZOIC ACID, 4-FORMYL-, PHENYLMETHYL ESTER

Base Information

• Chemical Name: BENZOIC ACID, 4-FORMYL-, PHENYLMETHYL ESTER
• CAS No.: 78767-55-2
• Molecular Formula: C15H12 O3
• Molecular Weight: 240.258
• Mol file: 78767-55-2.mol

Synonyms:4-(Benzyloxycarbonyl)benzaldehyde;4-Formylbenzoic acid benzyl ester

Chemical Property of BENZOIC ACID, 4-FORMYL-, PHENYLMETHYL ESTER

Chemical Property:

• PSA: 43.37000
• LogP: 2.85610

Purity/Quality:

95+% ^*data from raw suppliers

BENZOIC ACID, 4-FORMYL-, PHENYLMETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZOIC ACID, 4-FORMYL-, PHENYLMETHYL ESTER

There total 9 articles about BENZOIC ACID, 4-FORMYL-, PHENYLMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl bromide (100-39-0) + 4-Carboxybenzaldehyde (619-66-9) → benzyl 4-formylbenzoate (78767-55-2)

Guidance literature:

4-Carboxybenzaldehyde; With alkali metal carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.1c00201

Reference yield: 95.0%

4-Carboxybenzaldehyde (619-66-9) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 4-formylbenzoate (78767-55-2)

Guidance literature:

With 2-pyrrolidinopyridine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1039/a701968h

Reference yield: 94.0%

dibenzyl dicarbonate (31139-36-3) + 4-Carboxybenzaldehyde (619-66-9) → benzyl 4-formylbenzoate (78767-55-2)

Guidance literature:

magnesium(II) perchlorate; In nitromethane; at 40 ℃; for 16h;

DOI:10.1002/adsc.200303040

upstream raw materials:

4-Carboxybenzaldehyde

benzyl alcohol

4-Carbobenzoxyphenylaldoxime

benzyl bromide

Downstream raw materials:

4-Carbobenzoxyphenylaldoxime

4-[(dimethoxy-phosphoryl)-hydroxy-methyl]-benzoic acid benzyl ester

C₁₅H₂₁NO₄

C₂₄H₂₉N₃O₇

Refernces

• 1、 Takioku, Maho,Takamura, Yuta,Fujihara, Michiko,Watanabe, Masaki,Yamada, Shoya,Kawasaki, Mayu,Ito, Sohei,Nakano, Shogo,Kakuta, Hiroki. "Creation of Fluorescent RXR Antagonists Based on CBTF-EE and Application to a Fluorescence Polarization Binding Assay". supporting information. p. 1024 - 1029. Retrieved 2021/05/27.
• 2、 Toutah, Krimo,Nawar, Nabanita,Timonen, Sanna,Sorger, Helena,Raouf, Yasir S.,Bukhari, Shazreh,von Jan, Jana,Ianevski, Aleksandr,Gawel, Justyna M.,Olaoye, Olasunkanmi O.,Geletu, Mulu,Abdeldayem, Ayah,Israelian, Johan,Radu, Tudor B.,Sedighi, Abootaleb,Bhatti, Muzaffar N.,Hassan, Muhammad Murtaza,Manaswiyoungkul, Pimyupa,Shouksmith, Andrew E.,Neubauer, Heidi A.,de Araujo, Elvin D.,Aittokallio, Tero,Kr?mer, Oliver H.,Moriggl, Richard,Mustjoki, Satu,Herling, Marco,Gunning, Patrick T.. "Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia". . p. 8486 - 8509. Retrieved 2021/06/30.