7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid

Base Information

• Chemical Name: 7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid
• CAS No.: 28242-83-3
• Molecular Formula: C₁₆H₁₈N₂O₉S
• Molecular Weight: 414.393
• Mol file: 28242-83-3.mol

Synonyms:7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid

Chemical Property of 7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid

There total 2 articles about 7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

cephalosporin C (61-24-5) → 3-acetoxymethyl-7(R)-glutaroylaminoceph-3-em-4-carboxylic acid (27920-90-7) + 7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid (28242-83-3)

Guidance literature:

With oxygen; D-amino acid oxidase (immobilized on glyoxyl agarose); In phosphate buffer; at 25 ℃; for 3.33333h; pH=7.5; Enzymatic reaction;

DOI:10.1002/adsc.200505099

Reference yield: 80.0%

cephalosporin C (61-24-5) → 2-oxohexanedioic acid (3184-35-8) + 7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid (28242-83-3) + 7-Aminocephalosporanic acid (957-68-6)

Guidance literature:

With sodium hydroxide; D-amino acid oxidase; bovine catalase (on glyoxyl agarose); glutaryl acylase (immobilized on polyethyleneimine); In phosphate buffer; at 25 ℃; for 3h; pH=8; Enzymatic reaction;

DOI:10.1002/adsc.200505099

Reference yield:

7β-(5-carboxy-5-oxopentanamido)cephalosporanic acid (28242-83-3) → 2-oxohexanedioic acid (3184-35-8) + 7-Aminocephalosporanic acid (957-68-6)

Guidance literature:

With sodium hydroxide; glutaryl acylase (immobilized on polyethyleneimine); In phosphate buffer; at 25 ℃; for 0.5h; pH=8.0; Enzymatic reaction;

DOI:10.1002/adsc.200505099

upstream raw materials:

cephalosporin C

Downstream raw materials:

2-oxohexanedioic acid

7-Aminocephalosporanic acid

Refernces